ArticleProceedings of the National Academy of Sciences of the United States of America2021
Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 134 citations in OpenAlex.
- Violet light-transmitting intraocular lens increases choroidal thickness: 1-year prospective, randomised controlled trial.BMJ open ophthalmology · 2025Trial
- Photobiology in ophthalmology: from evolutionary adaptation to translational therapeutics.Japanese journal of ophthalmology · 2026Review
- Prevention of myopia in a near-primate by supplemental indigo light suggests a hypothesis for the myopia boom.Cell reports. Medicine · 2026Article
- Acute Ocular Effects of Violet and Red Light Exposure in Young Adults.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Analysis of real-world eye level light exposure through spectacle lens.Npj biological timing and sleep · 2026Article
- Anatomical and Transcriptional Alterations in the Mouse Choroid Induced by All-Trans Retinoic Acid.Investigative ophthalmology & visual science · 2026Article
- Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.Cell research · 2026Article
- Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.Investigative ophthalmology & visual science · 2026Article
- Correlation between retinal defocus distribution and axial growth in myopic children wearing orthokeratology lenses.BMC ophthalmology · 2026Article
- Light-at-night exposure drives myopia via melanopsin signalling.Science China. Life sciences · 2026Article
- Ocular Transmission of Red and Violet Light: Insights into Light-Based Myopia Therapies.Translational vision science & technology · 2026Article
- Review
- The Light-Eye-Brain Axis: Neurobiological Links Between Mood Disorders and Myopia-A Narrative Review.Ophthalmology and therapy · 2026Review
- Light and myopia: a focus on the expanding role of non-visual opsins.Eye and vision (London, England) · 2026Review
- Role of light in eye growth and light as a therapy for myopia control.Frontiers in ophthalmology · 2026Review
- Display color gamut as a spectral risk factor for myopia: a unifying hypothesis linking chromatic emmetropization, cone circuitry dysfunction, and the spectral deficiency of digital screens.Frontiers in ophthalmology · 2026Article
- Hypoxia-induced OPN5 expression is associated with matrix-preserving responses in human scleral fibroblasts.Frontiers in neuroscience · 2026Article
- Influence of light on myopia-a review.International journal of ophthalmology · 2026Review
- The physiological functions of OPN5m.Eye and vision (London, England) · 2025Review
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
28 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus-induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.