ArticleRegional anesthesia and pain medicine2021
Prospective, randomized, multicenter study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 12-month results.
Article in Regional anesthesia and pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Current evidence on radiofrequency denervation for chronic low back pain: a systematic review and meta-analysis.BMJ open · 2026Pooled it
- The Effectiveness of Intraosseous Basivertebral Nerve Radiofrequency Ablation for the Treatment of Vertebrogenic Low Back Pain: An Updated Systematic Review with Single-Arm Meta-analysis.Pain medicine (Malden, Mass.) · 2022Pooled it
- Sustained pain relief across modic subtypes following basivertebral nerve ablation: A real-world study.Interventional pain medicine · 2026Article
- The Sinuvertebral Nerve and Basivertebral Nerve: Analyzing the Central Role of the Vertebral-Disc Unit in Chronic Low Back Pain.Current pain and headache reports · 2026Review
- Durable pain relief following basivertebral nerve ablation in patients with prior lumbar decompression: A retrospective case series.Interventional pain medicine · 2026Article
- L5-S1 basivertebral nerve ablation for chronic vertebrogenic low back pain following lumbar fusion: a case report.Journal of spine surgery (Hong Kong) · 2026Article
- Vertebrogenic Low Back Pain and Basivertebral Nerve Ablation: A Review of Mechanisms, Imaging-Driven Selection, and Clinical Outcomes.Diagnostics (Basel, Switzerland) · 2026Review
- Early pain-response trajectories after basivertebral nerve ablation and their relationship to 12-month clinical outcomes.Interventional pain medicine · 2026Article
- The utility of SPECT-CT in identifying vertebral endplate changes for basivertebral nerve ablation: A retrospective study with MRI comparison.Interventional pain medicine · 2026Article
- The effectiveness of basivertebral nerve radiofrequency ablation for the treatment of vertebrogenic low back pain: 1-year results of a prospective real-world cohort study.Pain medicine (Malden, Mass.) · 2026Article
- Intervertebral disc degeneration.Nature reviews. Disease primers · 2026Review
- Modic changes and their role in vertebrogenic back pain: a literature review.Skeletal radiology · 2026Review
- Timing and trajectory of pain and functional outcomes after basivertebral nerve ablation: a prospective cohort study.Interventional pain medicine · 2025Article
- Subject: Letters to the editor: Re: rates of lumbar vertebral body compression fracture after basivertebral nerve ablation: A retrospective study utilizing a large national database.Interventional pain medicine · 2025Article
- Evaluating the effectiveness of 7-min basivertebral nerve ablation in treating vertebrogenic low back pain.Interventional pain medicine · 2025Article
- Synergistic Effects of Basivertebral Nerve Ablation Plus Schroth Therapy for Adult Scoliosis: A Multicenter Propensity-Matched Cohort Study.Pain and therapy · 2025Article
- Patient selection, clinical outcomes, associated healthcare utilization, and cost-effectiveness of basivertebral nerve ablation for the treatment of vertebrogenic low back pain: A narrative review.North American Spine Society journal · 2025Article
- Modic Changes as Biomarkers for Treatment of Chronic Low Back Pain.Biomedicines · 2025Review
- Notable concerns in methodology and conclusions of the Wang et al. Meta-analysis in BMJ by the American Academy of Pain Medicine.Pain medicine (Malden, Mass.) · 2025Article
- Decrease in opioid use and spinal interventions after basivertebral nerve ablation.Interventional pain medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionVertebral endplates, innervated by the basivertebral nerve (BVN), are a source of chronic low back pain correlated with Modic changes. A randomized trial comparing BVN ablation to standard care (SC) recently reported results of an interim analysis. Here, we report the results of the full randomized trial, including the 3-month and 6-month between-arm comparisons, 12-month treatment arm results, and 6-month outcomes of BVN ablation in the former SC arm.
methodsProspective, open label, 1:1 randomized controlled trial of BVN ablation versus SC in 23 US sites with follow-up at 6 weeks, 3, 6, 9, and 12 months. SC patients were re-baselined and followed up for 6 months post BVN ablation. The primary endpoint was the between-arm comparison of mean Oswestry Disability Index (ODI) change from baseline. Secondary endpoints were Visual Analog Scale (VAS), Short Form (SF-36), EuroQual Group 5 Dimension 5-Level Quality of Life (EQ-5D-5L), responder rates, and rates of continued opioid use.
results140 were randomized. Results from BVN ablation (n=66) were superior to SC (n=74) at 3 months for the primary endpoint (mean ODI reduction, difference between arms of -20.3 (CI -25.9 to -14.7 points; p<0.001)), VAS pain improvement (difference of -2.5 cm between arms (CI -3.37 to -1.64, p<0.001)) and quality of life outcomes. At 12 months, basivertebral ablation demonstrated a 25.7±18.5 point reduction in mean ODI (p<0.001), and a 3.8±2.7 cm VAS reduction (p<0.001) from baseline, with 64% demonstrating ≥50% reduction and 29% pain free. Similarly, the former SC patients who elected BVN ablation (92%) demonstrated a 25.9±15.5 point mean ODI reduction (p<0.001) from baseline. The proportion of opioid use did not change in either group (p=0.56). DISCUSSION/
conclusionBVN ablation demonstrates significant improvements in pain and function over SC, with treatment results sustained through 12 months in patients with chronic low back pain of vertebrogenic origin.
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