Evidence map›Paper›PMID 34031201›Full record

ArticleNeurology2021

Rare Missense Functional Variants at

Jaeyoon Chung, Graham Hamilton, Minsup Kim, Sandro Marini, Bailey Montgomery, Jonathan Henry, Art E Cho, Devin L Brown, Bradford B Worrall, James F Meschia and 21 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Genetics of intracerebral hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. International journal of medical sciences · 2024
    Article
  9. Review
  10. Article
  11. Rare and Common Variants inFrontiers in neurology · 2022
    Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 1 institution in 1 country.

Jaeyoon ChungFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0002-6431-9454
Graham HamiltonFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0001-6702-7724
Minsup KimFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0002-0053-2002
Sandro MariniFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Bailey MontgomeryFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Jonathan HenryFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Art E ChoFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Devin L BrownFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0002-9815-3421
Bradford B WorrallFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0001-9386-4091
James F MeschiaFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0002-4475-8142
Scott L SillimanFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Magdy SelimFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
David L TirschwellFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Chelsea S KidwellFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Brett KisselaFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0002-9773-4013
Steven M GreenbergFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Anand ViswanathanFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Joshua N GoldsteinFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0002-6406-1828
Carl D LangefeldFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Kristiina RannikmaeFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Catherine L M SudlowFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Neshika SamarasekeraFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0001-6840-0199
Mark RodriguesFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0002-4507-6872
Rustam Al-Shahi SalmanFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0002-2108-9222
James G D PrendergastFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.ORCID http://orcid.org/0000-0001-8916-018X
Sarah E HarrisFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Ian DearyFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Daniel WooFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Jonathan RosandFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA.
Tom Van AgtmaelFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA cdanderson@mgh.harvard.edu Tom.vanagtmael@glasgow.ac.uk.ORCID http://orcid.org/0000-0003-4282-449X
Christopher D AndersonFrom the Center for Genomic Medicine (J.C., S.M., B.M., J.H., J.R., C.D.A.), Department of Neurology (B.M., J.H., S.M.G., A.V., J.R., C.D.A.), McCance Center for Brain Health (J.H., J.R., C.D.A.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics (J.C., J.R., C.D.A.), Broad Institute, Boston, MA; Glasgow Polyomics, Wolfson Wohl Cancer Research Centre, Garscube Campus (G.H.), and Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (G.H., T.V.A.), University of Glasgow, Bearsden, UK; Department of Bioinformatics (M.K., A.E.C.), Korea University, Sejong, South Korea; Stroke Program, Department of Neurology (D.L.B.), University of Michigan, Ann Arbor; Department of Neurology and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Department of Neurology (J.F.M.), Mayo Clinic Jacksonville; Department of Neurology (S.L.S.), University of Florida College of Medicine, Jacksonville; Department of Neurology, Stroke Division (M.S.), Beth Israel Deaconess Medical Center, Boston, MA; Department of Neurology, Harborview Medical Center (D.L.T.), University of Washington, Seattle; Department of Neurology (C.S.K.), The University of Arizona, Tucson; Department of Neurology and Rehabilitation Medicine (B.K., D.W.), University of Cincinnati, OH; Center for Public Health Genomics and Department of Biostatistical Sciences (C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC; Centre for Medical Informatics, Usher Institute (K.R., C.L.M.S.), Centre for Clinical Brain Sciences (N.S., M.R., R.A.-S.S.), The Roslin Institute (J.G.D.P.), and Lothian Birth Cohorts Group, Department of Psychology (S.E.H., I.D.), University of Edinburgh; and British Heart Foundation Data Science Centre (K.R.), London, UK. Dr. Anderson is currently at the Department of Neurology, Brigham and Women's Hospital, Boston, MA cdanderson@mgh.harvard.edu Tom.vanagtmael@glasgow.ac.uk.
Jacobson Holman (United States) · US

Funding

Sequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4M
Medical Research Council G0700704Medical Research Council G0900428Medical Research Council G1002605Medical Research Council G108/613Medical Research Council MR/R005567/1Medical Research Council MR/S004130/1NINDS NIH HHS R01 NS103924
6 · The paper itself

Abstract

objectiveTo test the genetic contribution of rare missense variants in

methodsWe performed sequencing across 559 Kbp at 13q34 including

resultsWe identified 107 rare nonsynonymous variants in sporadic ICH, of which 2 missense variants, rs138269346 (COL4A1

conclusionsWe identified rare missense variants in

Identifiers

PMID34031201
PMCPMC8302151
OpenAlexW3164728066

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