Evidence map›Paper›PMID 34031163›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss.

Yang He, Hailan Liu, Na Yin, Yongjie Yang, Chunmei Wang, Meng Yu, Hesong Liu, Chen Liang, Julia Wang, Longlong Tu and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Defining Predictors of Weight Loss Response to Lorcaserin.The Journal of clinical endocrinology and metabolism · 2023
    Trial
  2. Article
  3. G proteins of the GScience advances · 2025
    Article
  4. Article
  5. A Light-Responsive Neural Circuit Suppresses Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Small molecules targeting endocytic uptake and recycling pathways.Frontiers in cell and developmental biology · 2023
    Review
  11. Signaling pathways in obesity: mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Yang HeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Hailan LiuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Na YinChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Yongjie YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Meng YuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Hesong LiuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Chen LiangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Julia WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Longlong TuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Nan ZhangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Lina WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Yanlin HeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Makoto FukudaChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.ORCID https://orcid.org/0000-0003-0112-9925
Qi WuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
Zheng SunDepartment of Internal Medicine, Baylor College of Medicine, Houston, Texas 77030.
Qingchun TongBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030.ORCID https://orcid.org/0000-0002-4561-2540
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030 yongx@bcm.edu.ORCID https://orcid.org/0000-0002-4908-1572
Baylor College of Medicine · USBrown Foundation · US

Funding

Project 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SREEKUMAR, ARUN · 2018 to 2022
$7.9M
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4M
Gender-Specific Effects of Arsenic in DiabetesR01ES027544 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2021
$2.2M
Epigenomic Remodeling of Metabolism by Exercise through AP-1R01DK111436 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SUN, ZHENG · 2017 to 2020
$2.0M
Hypothalamic Grb10 and body weightR01DK115761 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRAZER, ALAN, XU, YONG · 2018 to 2021
$2.0M
5-HT NEURONS INTEGRATE NEURAL INPUTS TO REGULATE FOOD INTAKER01DK120858 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TONG, QINGCHUN, XU, YONG · 2020 to 2023
$1.9M
Neurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8M
A Novel AgRP Neurons to the Dorsal Raphe Circuit in Control of Energy ExpenditureR01DK109194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2017 to 2021
$1.8M
Brain Estrogen Regulates Energy and Glucose BalanceR01DK125480 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2020 to 2023
$1.6M
A direct LH to PVH projection for antagonistic regulation of feedingR01DK114279 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2018 to 2021
$1.5M
To explore the mechanism underlying developmental compensations in PVH neuronsR21NS108091 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2019 to 2019
$426k
A TAP63 TRANSCRIPTIONAL AXIS CONTRIBUTES TO THE SEXUAL DIMORPHISM IN POMC NEURON FUNCTIONS AND ENERGY HOMEOSTASISK01DK119471 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WANG, CHUNMEI · 2019 to 2021
$391k
NIDDK NIH HHS K01 DK119471NIDDK NIH HHS P01 DK113954NIDDK NIH HHS R01 DK109194NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK111436NIDDK NIH HHS R01 DK114279NIDDK NIH HHS R01 DK115761NIDDK NIH HHS R01 DK117281NIDDK NIH HHS R01 DK120858NIDDK NIH HHS R01 DK125480NIDDK NIH HHS R56 DK109194NIEHS NIH HHS R01 ES027544NINDS NIH HHS R21 NS108091
6 · The paper itself

Abstract

Obesity is a serious global health problem because of its increasing prevalence and comorbidities, but its treatments are limited. The serotonin 2C receptor (5-HT

Indexed as

AnimalsAppetiteArcuate Nucleus of HypothalamusBenzazepinesMaleMiceMice, Inbred C57BLNeuronsPro-OpiomelanocortinPyrimidinesReceptor, Serotonin, 5-HT2CTimeWeight LossbarbadinBenzazepineslorcaserinPro-OpiomelanocortinPyrimidinesReceptor, Serotonin, 5-HT2C5-HT 2C receptorfood intakeGPCRhypothalamusobesity

Identifiers

PMID34031163
PMCPMC8244968
OpenAlexW3165581109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.