Evidence map›Paper›PMID 34030971›Full record

ReviewThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021

Influence of the microbiome on solid organ transplant survival.

Isabella Pirozzolo, Zhipeng Li, Martin Sepulveda, Maria-Luisa Alegre

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Delivery of butyrate to the lower gut by polymeric micelles prolongs survival of distal skin allografts.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  5. Article
  6. The Microbiome and Pediatric Transplantation.Journal of the Pediatric Infectious Diseases Society · 2024
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Isabella PirozzoloSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, Illinois.
Zhipeng LiSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, Illinois.
Martin SepulvedaSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, Illinois.
Maria-Luisa AlegreSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, Illinois. Electronic address: malegre@midway.uchicago.edu.
University of Chicago · US

Funding

University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7M
Impact of Microbiota on Alloimmune Responses in TransplantationR01AI115716 · NIAID · UNIVERSITY OF CHICAGO · PI ALEGRE, MARIA-LUISA · 2015 to 2024
$4.3M
The microbiota and allograft rejection: novel investigations into the consequences of obesityU01AI132898 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEGRE, MARIA-LUISA, PERKINS, DAVID LINN · 2017 to 2021
$2.3M
NIAID NIH HHS R01 AI115716NIAID NIH HHS U01 AI132898NIGMS NIH HHS R25 GM109439
6 · The paper itself

Abstract

The microbiome is an environmental factor in intricate symbiotic relationship with its hosts' immune system, potentially shaping anticancer immunity, autoimmunity, and transplant responses. The focus of this review is to discuss recent findings tying the microbiota to transplant outcomes and alloimmunity. The microbiota changes dynamically following transplantation, but whether these changes affect transplant outcomes can be difficult to parse out. New data reveal effects of the microbiota locally, as well as systemically, depending on the mucosal/epithelial surface colonized, the specific commensal communities present and the nature of microbial-derived molecules produced. These complex interactions result in the microbiota potentially impacting transplantation at different levels, including modulation of donor and/or recipient cells, alterations in the priming and/or effector phases of the alloimmune response, availability or metabolism of immunosuppressive drugs, transplant fate or post-transplant complications.

Indexed as

Organ TransplantationAdaptive ImmunityGraft RejectionHumansMicrobiotaTransplantation Tolerancealloimmunityimmunosuppressionmetabolitesmicrobiotaorgan transplantation

Identifiers

PMID34030971
PMCPMC8319047
OpenAlexW3152786710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.