ArticleBJPsych open2021
Mother-infant interaction in women with depression in pregnancy and in women with a history of depression: the Psychiatry Research and Motherhood - Depression (PRAM-D) study.
Article in BJPsych open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety, and Related Disorders: Guide de pratique 2024 du Canadian Network for Mood and Anxiety Treatments pour le traitement des troubles de l'humeur, des troubles anxieux et des troubles connexes périnatals.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2025Guideline
- A systematic review of clinical psychological guidance for perinatal mental health.BMC psychiatry · 2023Pooled it
- Clinical effectiveness, implementation effectiveness and cost-effectiveness of a community singing intervention for postnatal depressive symptoms, SHAPER-PND: randomised controlled trial.The British journal of psychiatry : the journal of mental science · 2025Trial
- HappyMums mobile application study protocol: use of a smartphone application to gather data predictive of antenatal depression.BMJ open · 2026Observational
- A psychometric evaluation of the NICHD Parent-Infant Interaction Scales to inform clinical practice.Frontiers in psychology · 2026Article
- Blood transcriptomic signatures associated with depression, or the risk for depression, in pregnant women from the Psychiatry Research And Motherhood - Depression (PRAM-D) study.Translational psychiatry · 2025Article
- The impact of gestational diabetes mellitus on perceived mother-infant bonding: a qualitative study.Journal of reproductive and infant psychology · 2025Article
- Peripartum Depression: What's New?Current psychiatry reports · 2025Review
- Prenatal maternal sleep and maternal-infant attachment: a systematic review.Frontiers in sleep · 2025Review
- Women with depression in pregnancy or a history of depression have decreased quality of mentalization in the speech to their infants.Acta psychiatrica Scandinavica · 2024Article
- Associations between mothers' and fathers' depression and anxiety prior to birth and infant temperament trajectories over the first year of life: Evidence from diagnoses and symptom severity.Journal of affective disorders · 2023Article
- Coding Dyadic Behavior in Caregiver-Child Interaction from a Clinical Psychology Perspective: How Should Multiple Instruments and Outcomes Be Dealt with?Children (Basel, Switzerland) · 2023Article
- Gestational diabetes mellitus and its impact on the mother-infant relationship: A cohort study in the postnatal period.Preventive medicine reports · 2023Article
- Feasibility, clinical efficacy, and well-being outcomes of an online singing intervention for postnatal depression in the UK: SHAPER-PNDO, a single-arm clinical trial.Pilot and feasibility studies · 2023Article
- The impact of the second COVID-19 lockdown on anxiety and depressive symptoms in pregnant women: A case study of pregnant women in northern Italy.Brain, behavior, & immunity - health · 2023Article
- Should Antidepressants be Avoided in Pregnancy?Drug safety · 2023Review
- Online singing interventions for postnatal depression in times of social isolation: a feasibility study protocol for the SHAPER-PNDO single-arm trial.Pilot and feasibility studies · 2022Article
- Immunological and other biological correlates of the impact of antenatal depression on the mother-infant relationship.Brain, behavior, & immunity - health · 2022Article
- An Interprofessional Approach to Teaching About Postpartum Depression.Journal of midwifery & women's healthArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLittle is known about the effects of depression before birth on the quality of the mother-infant interaction.
aimsTo understand whether depression, either in pregnancy or in lifetime before pregnancy, disrupts postnatal mother-infant interactions.
methodWe recruited 131 pregnant women (51 healthy, 52 with major depressive disorder (MDD) in pregnancy, 28 with a history of MDD but healthy pregnancy), at 25 weeks' gestation. MDD was confirmed with the Structured Clinical Interview for DSM-IV Disorders. Neonatal behaviour was assessed at 6 days with the Neonatal Behavioural Assessment Scale, and mother-infant interaction was assessed at 8 weeks and 12 months with the Crittenden CARE-Index.
resultsAt 8 weeks and 12 months, dyads in the depression and history-only groups displayed a reduced quality of interaction compared with healthy dyads. Specifically, at 8 weeks, 62% in the depression group and 56% in the history-only group scored in the lowest category of dyadic synchrony (suggesting therapeutic interventions are needed), compared with 37% in the healthy group (P = 0.041); 48% and 32%, respectively, scored the same at 12 months, compared with 14% in the healthy group (P = 0.003). At 6 days, neonates in the depression and history-only groups exhibited decreased social-interactive behaviour, which, together with maternal socioeconomic difficulties, was also predictive of interaction quality, whereas postnatal depression was not.
conclusionsBoth antenatal depression and a lifetime history of depression are associated with a decreased quality of mother-infant interaction, irrespective of postnatal depression. Clinicians should be aware of this, as pregnancy provides an opportunity for identification and intervention to support the developing relationship.
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