ReviewInternational journal for parasitology. Drugs and drug resistance2021
Heartworm disease - Overview, intervention, and industry perspective.
Review in International journal for parasitology. Drugs and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed.
- Improved specificity of a probe-based real-time PCR for the detection of Dirofilaria immitis in canine blood.Parasites & vectors · 2026Article
- Fluorescence videography for the rapid and automated in-clinic detection of microfilariae.Parasites & vectors · 2026Article
- Treatment of heartworm (Dirofilaria immitis) disease in dogs in the USA: general findings and cost of disease.Parasites & vectors · 2026Article
- Efficacy of a combination of fipronil and permethrin in reducing the risk of Dirofilaria immitis transmission to dogs in field conditions.Parasites & vectors · 2026Article
- The American Heartworm Society and Association of Shelter Veterinarians' 2024 Shelter Heartworm Management Practices Survey.Parasites & vectors · 2026Article
- Seroprevalence of Dirofilaria immitis in traveling dogs: implications for transboundary pathogen movement.Parasites & vectors · 2026Article
- Comparative performance of the novel, point-of-care Pluslife Mini Dock Dirofilaria immitis/Dirofilaria repens detection test with the modified Knott's test in dogs.Parasites & vectors · 2026Article
- Efficacy and safety of a sustained-release formulation of ivermectin (FILAPREV®) in preventing heartworm infection (Dirofilaria immitis) in dogs in two endemic areas of Italy.Parasites & vectors · 2026Article
- Efficacy of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs.Parasites & vectors · 2026Article
- Global Research Trends in Emerging Zoonosis Due to (the Filarial Nematode)Pathogens (Basel, Switzerland) · 2026Article
- Mapping Global Trends inAnimals : an open access journal from MDPI · 2026Article
- Goondoxazoles A-C: Anthelmintic Spiroketal Polyketide Alkaloids and Other Benzoxazoles from Australian Pasture Soil-DerivedAntibiotics (Basel, Switzerland) · 2026Article
- Development of Dirofilaria immitis adult worms in NSG mice, detection of parasite-derived microRNA and comparative analysis of laboratory isolates.Scientific reports · 2026Article
- Population genomics reveals an ancient origin of heartworms in canids.Communications biology · 2026Article
- Presence ofCurrent research in parasitology & vector-borne diseases · 2026Article
- Zoonotic endoparasites and Toxoplasma gondii seropositivity in free-roaming cats (Felis catus) from New York City boroughs.PloS one · 2026Article
- Effects of Oral Macrocyclic Lactone Heartworm Preventatives on Retinal Function and Chromatic Pupillary Light Reflex in Healthy Companion Dogs.Veterinary ophthalmology · 2026Article
- Old drugs, new weapons: current trends in repurposing therapies against antimicrobial resistance.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2026Review
- Ivermectin in veterinary medicine: a narrative review of antiparasitic efficacy, resistance evolution, antiviral evidence, and One Health implications.Frontiers in veterinary science · 2026Review
- A systematic review and meta-analysis of non-arsenical adulticide protocols using moxidectin and doxycycline for the treatment of adult heartworm infection in dogs.Current research in parasitology & vector-borne diseases · 2026Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dirofilaria immitis, also known as heartworm, is a major parasitic threat for dogs and cats around the world. Because of its impact on the health and welfare of companion animals, heartworm disease is of huge veterinary and economic importance especially in North America, Europe, Asia and Australia. Within the animal health market many different heartworm preventive products are available, all of which contain active components of the same drug class, the macrocyclic lactones. In addition to compliance issues, such as under-dosing or irregular treatment intervals, the occurrence of drug-resistant heartworms within the populations in the Mississippi River areas adds to the failure of preventive treatments. The objective of this review is to provide an overview of the disease, summarize the current disease control measures and highlight potential new avenues and best practices for treatment and prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.