ArticleJournal of affective disorders2021
Melanopsin-driven pupil response in summer and winter in unipolar seasonal affective disorder.
Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Sex and age modulate the relationship between melanopsin-dependent light sensitivity and chronotype.Sleep · 2026Article
- A study on electroretinography as a biomarker for seasonal vulnerability in depression.Translational psychiatry · 2025Article
- The role of sunlight in sleep regulation: analysis of morning, evening and late exposure.BMC public health · 2025Article
- Pupillometric and perceptual approaches provide independent estimates of melanopsin activity in humans.Sleep · 2025Article
- Observational
- One seasonal clock fits all?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Altered pupil light and darkness reflex and eye-blink responses in late-life depression.BMC geriatrics · 2024Article
- Article
- Sleep and circadian rhythm profiles in seasonal depression.Journal of psychiatric research · 2022Article
- Sleep and circadian differences between light and heavy adult alcohol drinkers.Alcoholism, clinical and experimental research · 2022Article
- Article
- Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology.Bipolar disorders · 2022Review
- Publication guidelines and recommendations for pupillary measurement in psychophysiological studies.Psychophysiology · 2022Article
- Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
A retinal subsensitivity to environmental light may trigger Seasonal Affective Disorder (SAD) under low wintertime light conditions. The main aim of this study was to assess the responses of melanopsin-containing retinal ganglion cells in participants (N= 65) diagnosed with unipolar SAD compared to controls with no history of depression. Participants attended a summer visit, a winter visit, or both. Retinal responses to light were measured using the post-illumination pupil response (PIPR) to assess melanopsin-driven responses in the non-visual light input pathway. Linear mixed-effects modeling was used to test a group*season interaction on the Net PIPR (red minus blue light response, percent baseline). We observed a significant group*season interaction such that the PIPR decreased from summer to winter significantly in the SAD group while not in the control group. The SAD group PIPR was significantly lower in winter compared to controls but did not differ between groups in summer. Only 60% of the participants underwent an eye health exam, although all participants reported no history of retinal pathology, and eye exam status was neither associated with outcome nor different between groups. This seasonal variation in melanopsin driven non-visual responses to light may be a risk factor for SAD, and further highlights individual differences in responses to light for direct or indirect effects of light on mood.
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Registered trials
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