Evidence map›Paper›PMID 34029863›Full record

ArticleSocial science & medicine (1982)2021

The effects of education on cognition in older age: Evidence from genotyped Siblings.

Jason Fletcher, Michael Topping, Fengyi Zheng, Qiongshi Lu

Open access · greenAbstract read
In one paragraph

Article in Social science & medicine (1982), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
15.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. The social environment and cognitive aging over the life course: laying out critical concepts and research gaps.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
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  8. APOE genotype and cognitive decline: educational context as a moderator of genetic risk.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jason FletcherLa Follette School of Public Affairs and Department of Sociology, Center for Demography of Health and Aging, University of Wisconsin-Madison, USA. Electronic address: jason.fletcher@wisc.edu.
Michael ToppingDepartment of Sociology, Center for Demography of Health and Aging, University of Wisconsin-Madison, USA. Electronic address: mtopping@wisc.edu.
Fengyi ZhengDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, USA. Electronic address: fzheng28@wisc.edu.
Qiongshi LuDepartment of Biostatistics and Medical Informatics, Center for Demography of Health and Aging, University of Wisconsin-Madison, USA. Electronic address: qlu@biostat.wisc.edu.
University of Wisconsin–Madison · US

Funding

Statistical Data Enclave CoreP30AG017266 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Michal Engelman · 1999 to 2026
$17.0M
The Importance of Place in Determining Health and Mortality at Older AgesR01AG060109 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI FLETCHER, JASON MICHAEL, PALLONI, ALBERTO B. · 2018 to 2022
$2.2M
The Importance of Place of Birth in Determining Old Age Cognitive HealthRF1AG062765 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI FLETCHER, JASON MICHAEL, PALLONI, ALBERTO B. · 2019 to 2019
$1.6M
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NIA NIH HHS P30 AG017266NIA NIH HHS R01 AG060109NIA NIH HHS RF1 AG062765
6 · The paper itself

Abstract

A growing literature has sought to tie educational attainment with later-life cognition and Alzheimer's disease outcomes. This paper leverages sibling comparisons in educational attainment as well as genetic predictors (polygenic scores) for cognition, educational attainment, and Alzheimer's disease to estimate effects of educational attainment on cognition in older age in the United Kingdom. We find that the effects of education on cognition are confounded by family background factors (~40%) and by genetics (<10%). After adjustments, we continue to find large effects of education. College graduates have cognition scores that are approximately 0.75 SD higher than those who report no credentials. We also find evidence that educational effects on cognition are smaller for those with high polygenic scores for Alzheimer's disease.

Indexed as

Academic SuccessSiblingsAgedCognitionEducational StatusHumansUnited KingdomEducationGene-environment interactionsOld age cognitionSibling fixed effectsUK Biobank

Identifiers

PMID34029863
PMCPMC8205990
OpenAlexW3162010007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.