ArticleCortex; a journal devoted to the study of the nervous system and behavior2021
Network topology of the cognitive phenotypes of temporal lobe epilepsy.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- The network neuropsychology of neighborhood deprivation in juvenile myoclonic epilepsy.Scientific reports · 2026Article
- Prospective neuroimaging and neuropsychological evaluation in adults with newly diagnosed focal epilepsy.Epilepsia · 2025Article
- The network neuropsychology of juvenile myoclonic epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Article
- Unveiling the cognitive network organization through cognitive performance.Scientific reports · 2024Article
- Epilepsy is associated with the accelerated aging of brain activity in sleep.Frontiers in physiology · 2024Article
- Electroencephalography derived connectivity informing epilepsy surgical planning: Towards clinical applications and future perspectives.NeuroImage. Clinical · 2024Review
- Brain functional network changes in patients with juvenile myoclonic epilepsy: a study based on graph theory and Granger causality analysis.Frontiers in neuroscience · 2024Article
- Unified topological inference for brain networks in temporal lobe epilepsy using the Wasserstein distance.NeuroImage · 2023Article
- Article
- Cognitive phenotypes in late-onset epilepsy: results from the atherosclerosis risk in communities study.Frontiers in neurology · 2023Article
- Cognitive phenotypes in frontal lobe epilepsy.Epilepsia · 2022Article
- Moving towards a taxonomy of cognitive impairments in epilepsy: application of latent profile analysis to 1178 patients with temporal lobe epilepsy.Brain communications · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe neuropsychological complications of temporal lobe epilepsy are characterized by a spectrum of reproducible cognitive phenotypes that vary in the presence, type and degree of impairment. The nature of the disruptions to the neuropsychological networks that underlie these phenotypes remain to be characterized and represent the subject of this investigation.
methodsParticipants included 30 healthy controls and 104 patients with temporal lobe epilepsy who fell into three cognitive phenotypes (intact, focal impairment, generalized impairment). Eighteen neuropsychological measures representing multiple cognitive domains (language, memory, executive function, visuoperception, motor speed) were examined by graph theory techniques within the control and each epilepsy cognitive phenotype group to characterize their global and local network properties.
resultsAcross the control and epilepsy cognitive phenotype groups (intact to focal to generalized impairment), there was: 1) an orderly breakdown in the positive manifold reflected by a stepwise reduction of positive associations among the neuropsychological tests, 2) stepwise abnormal increases in global measures including the normalized clustering coefficient and modularity index, 3) stepwise abnormal decreases in normalized global efficiency, 4) a community structure demonstrating well organized modules within the control group while each epilepsy group showed deviations from controls, and 5) lower strength, compared to controls, across 8 nodes in the focal and generalized impairment groups compared to only 3 nodes in the no-impairment epilepsy group, pointing to the superior integration of local connections in controls. DISCUSSION: The cognitive phenotypes of temporal lobe epilepsy are characterized by orderly abnormalities in their underlying neuropsychological networks. These findings inform the network perturbations that underlie the taxonomy of cognitive abnormality in temporal lobe epilepsy and provide a model for examination of similar issues in other focal and generalized epilepsies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.