SynthesisEcotoxicology and environmental safety2021
Association between pesticide exposure and colorectal cancer risk and incidence: A systematic review.
Synthesis in Ecotoxicology and environmental safety, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 79 citations in OpenAlex.
- Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives.Current environmental health reports · 2026Review
- Why Is Colorectal Cancer Occurring Earlier? Metabolic Dysfunction, Underrecognized Carcinogens, and Emerging Controversies.Current obesity reports · 2026Review
- Article
- Analysis and Risk Assessment of Pesticide Residues in Strawberry Using the PRIMo Model: Detection, Public Health and Safety Implications.Foods (Basel, Switzerland) · 2025Article
- Midwest Urban-Rural Differences in Cancer Prevalence.Mayo Clinic proceedings · 2025Article
- Occupational pesticide use and relative leukocyte telomere length in the biomarkers of exposure and effect in agriculture study.Environmental research · 2025Article
- Carcinogenic air pollutants and breast cancer risk in the Arkansas rural community health study: A nested case-control study.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Geographical disparities in cancer and occupational exposure to pesticides in a French-West Indies territory (2006-2019).BMC cancer · 2024Article
- Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies.Journal of health & pollution · 2024Review
- Could environmental exposure and climate change Be a key factor in the rising incidence of early onset colorectal cancer?Heliyon · 2024Review
- Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study.Environmental research · 2024Article
- Perspective: Nutrition Health Disparities Framework: A Model to Advance Health Equity.Advances in nutrition (Bethesda, Md.) · 2024Article
- Flavonoids as Insecticides in Crop Protection-A Review of Current Research and Future Prospects.Plants (Basel, Switzerland) · 2024Review
- A Comprehensive Analysis of Organic Food: Evaluating Nutritional Value and Impact on Human Health.Foods (Basel, Switzerland) · 2024Review
- Review
- Geographical Distribution of Colorectal Cancer in Southwestern Iran Between Years 2011 and 2019.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Bio-fabrication of zinc oxide nanoparticles from Picea smithiana and their potential antimicrobial activities against Xanthomonas campestris pv. Vesicatoria and Ralstonia solanacearum causing bacterial leaf spot and bacterial wilt in tomato.World journal of microbiology & biotechnology · 2023Article
- Adverse health effects of emerging contaminants on inflammatory bowel disease.Frontiers in public health · 2023Review
- Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated.Frontiers in public health · 2023Article
- Geospatial Assessment of Pesticide Concentration in Ambient Air and Colorectal Cancer Incidence in Arkansas, 2013-2017.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStudies investigating the association between pesticide exposure and colorectal cancer (CRC) risk have been inconclusive.
objectivesInvestigate the association between pesticide exposure and CRC risk through a systematic literature review.
methodsCRC has the fourth-highest rate of cancer-caused death in the US after lung cancer, breast cancer in women, and prostate cancer in men. Here we have conducted a systematic literature search on studies examining the association between any pesticide exposure and CRC risk using PubMed, MEDLINE via EBSCO host, and Embase according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist.
resultsFollowing the review, 139 articles were included for qualitative evaluation. Study participants were farmers, pesticide applicators, pesticide manufacturers, spouses of pesticide applicators, farm residents, Korean veterans of the Vietnam War, rural communities, and those who consumed food with pesticide residues. The studies' results were split between those with significant positive (39 significant results) and inverse (41 significant results) associations when comparing pesticide exposure and CRC risk. DISCUSSION: From our literature review, we have identified a similar number of significant positive and inverse associations of pesticide exposure with CRC risk and therefore cannot conclude whether pesticide exposure has a positive or inverse association with CRC risk overall. However, certain pesticides such as terbufos, dicamba, trifluralin, S-ethyl dipropylthiocarbamate (EPTC), imazethapyr, chlorpyrifos, carbaryl, pendimethalin, and acetochlor are of great concern not only for their associated elevated risk of CRC, but also for the current legal usage in the United States (US). Aldicarb and dieldrin are of moderate concern for the positive associations with CRC risk, and also for the illegal usage or the detection on imported food products even though they have been banned in the US. Pesticides can linger in the soil, water, and air for weeks to years and, therefore, can lead to exposure to farmers, manufacturing workers, and those living in rural communities near these farms and factories. Approximately 60 million people in the US live in rural areas and all of the CRC mortality hotspots are within the rural communities. The CRC mortality rate is still increasing in the rural regions despite the overall decreasing of incidence and mortality of CRC elsewhere. Therefore, the results from this study on the relationship between pesticide exposure and CRC risk will help us to understand CRC health disparities.
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