Evidence map›Paper›PMID 34029738›Full record

ArticleNeuroImage2021

Magnus Herberthson, Deneb Boito, Tom Dela Haije, Aasa Feragen, Carl-Fredrik Westin, Evren Özarslan

Abstract read
In one paragraph

Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Human In Vivo Validation of Frequency-Dependent QTI.Magnetic resonance in medicine · 2026
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  9. Diffusivity-limited q-space trajectory imaging.Magnetic resonance letters · 2023
    Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Magnus HerberthsonDepartment of Mathematics, Linköping University, Linköping, Sweden. Electronic address: magnus.herberthson@liu.se.
Deneb BoitoDepartment of Biomedical Engineering, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden. Electronic address: deneb.boito@liu.se.
Tom Dela HaijeDepartment of Computer Science, University of Copenhagen, Copenhagen, Denmark. Electronic address: haije@di.ku.dk.
Aasa FeragenDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, Lyngby, Denmark. Electronic address: afhar@dtu.dk.
Carl-Fredrik WestinLaboratory for Mathematics in Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: westin@bwh.harvard.edu.
Evren ÖzarslanDepartment of Biomedical Engineering, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden. Electronic address: evren.ozarslan@liu.se.

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9M
Novel DT-MRI Analyses of White Matter in SchizophreniaR01MH074794 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI WESTIN, CARL-FREDRIK · 2007 to 2021
$9.6M
NIBIB NIH HHS P41 EB015902NIMH NIH HHS R01 MH074794
6 · The paper itself

Abstract

Q-space trajectory imaging (QTI) enables the estimation of useful scalar measures indicative of the local tissue structure. This is accomplished by employing generalized gradient waveforms for diffusion sensitization alongside a diffusion tensor distribution (DTD) model. The first two moments of the underlying DTD are made available by acquisitions at low diffusion sensitivity (b-values). Here, we show that three independent conditions have to be fulfilled by the mean and covariance tensors associated with distributions of symmetric positive semidefinite tensors. We introduce an estimation framework utilizing semi-definite programming (SDP) to guarantee that these conditions are met. Applying the framework on simulated signal profiles for diffusion tensors distributed according to non-central Wishart distributions demonstrates the improved noise resilience of QTI+ over the commonly employed estimation methods. Our findings on a human brain data set also reveal pronounced improvements, especially so for acquisition protocols featuring few number of volumes. Our method's robustness to noise is expected to not only improve the accuracy of the estimates, but also enable a meaningful interpretation of contrast in the derived scalar maps. The technique's performance on shorter acquisitions could make it feasible in routine clinical practice.

Indexed as

BrainDiffusion Tensor ImagingHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMagnetic Resonance ImagingNeuroimagingConstrainedCovarianceDiffusionmddMRIMicroscopic anisotropyMRIMultidimensionalPositive definiteQTI

Identifiers

PMID34029738
PMCPMC9596133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.