Evidence map›Paper›PMID 34029686›Full record

ArticleThe journal of pain2021

Effects of Vancomycin on Persistent Pain-Stimulated and Pain-Depressed Behaviors in Female Fischer Rats With or Without Voluntary Access to Running Wheels.

Emily Payne, Kylee Harrington, Philomena Richard, Rebecca Brackin, Ravin Davis, Sarah Couture, Jacob Liff, Francesca Asmus, Elizabeth Mutina, Anyssa Fisher and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. DPsychopharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Emily PayneDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Kylee HarringtonDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Philomena RichardDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Rebecca BrackinDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Ravin DavisDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Sarah CoutureDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Jacob LiffDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Francesca AsmusDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Elizabeth MutinaDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Anyssa FisherDepartment of Psychology, University of New England, Biddeford, ME, 04005.
Denise GiuvelisDepartment of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005.
Sebastien SannajustDepartment of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005.
Bahman RostamaDepartment of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, 04005.
Tamara KingDepartment of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, 04005.
Lisa M MatteiDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Jung-Jin LeeDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Elliot S FriedmanDivision of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104.
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Meghan MayDepartment of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, ME, 04005; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, 04005.
Glenn W StevensonDepartment of Psychology, University of New England, Biddeford, ME, 04005; Center for Excellence in the Neurosciences, University of New England, Biddeford, ME, 04005. Electronic address: gstevenson@une.edu.
University of New England · USNew England College · USChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Tissue resident macrophages in sensory ganglia: function and impact on nociceptionP20GM103643 · NIGMS · UNIVERSITY OF NEW ENGLAND · PI MENG, IAN D · 2012 to 2021
$20.9M
NIGMS NIH HHS P20 GM103643
6 · The paper itself

Abstract

The present experiments determined the effects of the narrow-spectrum antibiotic vancomycin on inflammatory pain-stimulated and pain-depressed behaviors in rats. Persistent inflammatory pain was modeled using dilute formalin (0.5%). Two weeks of oral vancomycin administered in drinking water attenuated Phase II formalin pain-stimulated behavior, and prevented formalin pain-depressed wheel running. Fecal microbiota transplantation produced a non-significant trend toward reversal of the vancomycin effect on pain-stimulated behavior. Vancomycin depleted Firmicutes and Bacteroidetes populations in the gut while having a partial sparing effect on Lactobacillus species and Clostridiales. The vancomycin treatment effect was associated with an altered profile in amino acid concentrations in the gut with increases in arginine, glycine, alanine, proline, valine, leucine, and decreases in tyrosine and methionine. These results indicate that vancomycin may have therapeutic effects against persistent inflammatory pain conditions that are distal to the gut. PERSPECTIVE: The narrow-spectrum antibiotic vancomycin reduces pain-related behaviors in the formalin model of inflammatory pain. These data suggest that manipulation of the gut microbiome may be one method to attenuate inflammatory pain amplitude.

Indexed as

Amino AcidsAnimalsAnti-Bacterial AgentsBehavior, AnimalDisease Models, AnimalFemaleGastrointestinal MicrobiomeInflammationMotor ActivityPainRatsRats, Inbred F344VancomycinAmino AcidsAnti-Bacterial AgentsVancomycinamino acidsantibioticsgut microbiomePain-depressed behaviorsratswheel running

Identifiers

PMID34029686
PMCPMC8578155
OpenAlexW3164960538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.