Evidence map›Paper›PMID 34029685›Full record

Observational studyThe journal of pain2021

Pain and Trauma: The Role of Criterion A Trauma and Stressful Life Events in the Pain and PTSD Relationship.

Marianna Gasperi, Niloofar Afari, Jack Goldberg, Pradeep Suri, Matthew S Panizzon

Abstract readObservational StudyTwin Study
In one paragraph

Observational study in The journal of pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
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  12. Article
  13. Vicarious trauma among legal practitioners and judicial officers.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2024
    Article
  14. Article
  15. Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome.medRxiv : the preprint server for health sciences · 2023
    Article
  16. Striatal dopamine in anhedonia: A simultaneous [Psychiatry research. Neuroimaging · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marianna GasperiVA Center of Excellence for Stress and Mental Health, San Diego, California; Research Service, VA San Diego Healthcare System, San Diego, California; Department of Psychiatry, University of California, San Diego, La Jolla, California. Electronic address: mgasperi@health.ucsd.edu.
Niloofar AfariVA Center of Excellence for Stress and Mental Health, San Diego, California; Research Service, VA San Diego Healthcare System, San Diego, California; Department of Psychiatry, University of California, San Diego, La Jolla, California.
Jack GoldbergUniversity of Washington, Seattle, Washington; Vietnam Era Twin Registry, Seattle, Washington; Seattle Epidemiologic Research and Information Center (ERIC), Department of Veterans Affairs Office of Research and Development, Seattle, Washington.
Pradeep SuriSeattle Epidemiologic Research and Information Center (ERIC), Department of Veterans Affairs Office of Research and Development, Seattle, Washington; Rehabilitation Care Services, VA Puget Sound Health Care System, Seattle, Washington; Department of Rehabilitation Medicine, University of Washington, Seattle, Washington.
Matthew S PanizzonVA Center of Excellence for Stress and Mental Health, San Diego, California; Center for Behavior Genetics of Aging, University of California, San Diego, California.

Funding

WSU Urologic Chronic Pelvic Pain Syndromes Discovery CenterU01DK082325 · NIDDK · WASHINGTON STATE UNIVERSITY · PI BOGIC, MARIJA · 2008 to 2021
$9.0M
Testosterone-Androgen Receptor Genetics: Role in Cognitive and Biological AgingK08AG047903 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PANIZZON, MATTHEW S · 2014 to 2017
$452k
Chronic pain conditions and internalizing psychopathology, a genetic epidemiology investigation.IK2CX002107 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI Marianna Gasperi · 2021 to 2026
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A Twin Study of Chronic Back Pain and Associated Disability in VeteransIK2RX001515 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI SURI, PRADEEP · 2015 to 2018
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CSRD VA IK2 CX002107NIA NIH HHS K08 AG047903NIDDK NIH HHS U01 DK082325RRD VA IK2 RX001515
6 · The paper itself

Abstract

Chronic pain and post-traumatic stress disorder (PTSD) frequently co-occur, and research suggests that these 2 conditions exacerbate one another producing greater impact on normal functioning in combination than separately. The influence of traumatic experiences on both pain and PTSD has been shown, but the nature of this interplay remains unclear. Although Criterion A trauma is required for the diagnosis of PTSD, whether the association between PTSD and chronic pain is dependent on Criterion A is underexplored. In this observational cohort study, we examined the association between pain and PTSD-like symptoms in the context of Criterion A trauma in 5,791 men from the Vietnam Era Twin Registry. Correlations and mixed-effects regression models were used to evaluate the relationship between PTSD Checklist-Civilian Version symptoms and multiple indicators of pain from the Short Form McGill Pain Questionnaire across trauma history and chronic pain conditions. 53.21% of the participants experienced trauma consistent with DSM-IV Criterion A for PTSD. The associations between pain indicators and PTSD-like symptoms was stronger for individuals with a history of trauma but remained robust for individuals without trauma history. Small but significant interactions between past trauma and pain indicators and PTSD-like symptoms were observed. Findings were similar in a subsample of participants with history of chronic pain conditions. The relationship between PTSD-like symptoms and indicators of pain were largely independent of trauma consistent with Criterion A, highlighting the need to better understand and address stressful life events in chronic pain patients and pain concerns in individuals reporting trauma. PERSPECTIVE: This article demonstrates that the relationship between PTSD-like symptoms and indicators of pain is largely independent of trauma consistent with Criterion A. This finding highlights the need to better understand and address stressful life events in chronic pain patients and pain concerns in individuals reporting trauma.

Indexed as

RegistriesVeteransAgedChronic PainComorbidityHumansLife Change EventsMaleMiddle AgedPsychological TraumaStress Disorders, Post-TraumaticStress, PsychologicalUnited StatesPain intensityPost-traumatic stress disorderStressful life eventsTraumaVeterans

Identifiers

PMID34029685
PMCPMC8578317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.