Evidence map›Paper›PMID 34029610›Full record

ArticleExperimental neurology2021

Effects of altered tau expression on dentate granule cell excitability in mice.

Ryan A Cloyd, John Koren, Jose F Abisambra, Bret N Smith

Open access · greenAbstract read
In one paragraph

Article in Experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. The Bidirectional Relationship Between Epilepsy and Alzheimer's Disease.Current neurology and neuroscience reports · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Deregulated Transcription and Proteostasis in AdultInternational journal of molecular sciences · 2023
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ryan A CloydDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
John KorenDepartment of Neuroscience & Center for Translational Research in Neurodegenerative Diseases, University of Florida, Gainesville, FL 32610, USA.
Jose F AbisambraDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Neuroscience & Center for Translational Research in Neurodegenerative Diseases, University of Florida, Gainesville, FL 32610, USA.
Bret N SmithDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Electronic address: bret.smith@uky.edu.
University of Florida · USUniversity of Kentucky · US

Funding

NRSA Training CoreTL1TR001997 · NCATS · UNIVERSITY OF KENTUCKY · PI PENDERGAST, JULIE S, STOOPS, WILLIAM WALTON · 2016 to 2025
$4.2M
Contribution of adult neurogenesis to epileptogenesis and recovery after TBIR01NS092552 · NINDS · UNIVERSITY OF KENTUCKY · PI SMITH, BRET N · 2018 to 2022
$2.1M
PERK as a Central Mediator of Neurotoxicity in TauopathiesR01NS091329 · NINDS · UNIVERSITY OF KENTUCKY · PI ABISAMBRA, JOSE FRANCISCO · 2015 to 2019
$1.6M
Graduate Training in Integrative PhysiologyT32GM118292 · NIGMS · UNIVERSITY OF KENTUCKY · PI CAMPBELL, KENNETH S · 2017 to 2021
$999k
NCATS NIH HHS TL1 TR001997NIGMS NIH HHS T32 GM118292NINDS NIH HHS R01 NS091329NINDS NIH HHS R01 NS092552
6 · The paper itself

Abstract

Tauopathies, including Alzheimer's disease, are characterized by progressive accumulation of hyperphosphorylated and pathologic tau protein in association with onset of cognitive and behavioral impairment. Tau pathology is also associated with increased susceptibility to seizures and epilepsy, with tau

Indexed as

Age FactorsAnimalsDentate GyrusExcitatory Postsynaptic PotentialsFemaleGene ExpressionHumansMaleMembrane PotentialsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicOrgan Culture Techniquestau ProteinsMapt protein, mousetau ProteinsDentate granule cellEPSCHippocampushtauMicrotubule associated protein tauTau(−/−)Tauopathy

Identifiers

PMID34029610
PMCPMC8286323
OpenAlexW3162499653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.