ReviewAdvanced healthcare materials2021
Electrode Materials for Chronic Electrical Microstimulation.
Review in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Selective activation of nerve fiber subpopulations with intrafascicular stimulation.Journal of neural engineering · 2026Article
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Multiscale Engineering of Ion-Conducting Gels for Sustainable Bioelectronic Systems.Small methods · 2026Review
- Using a single penetrating interfascicular electrode to improve spatial selectivity of an extraneural polymeric cuff array.Bioelectronic medicine · 2025Article
- Nongenetic Photostimulation of hiPSC Neurons Using Plasmonic Nanopyramids.ACS photonics · 2025Article
- Bioadhesive and conformable bioelectronic interfaces for vasomotoricity monitoring and regulation.Nature communications · 2025Article
- Bidirectional mechanisms and emerging strategies for implantable bioelectronic interfaces.Bioactive materials · 2025Review
- Electrical Stimulation of Cells: Drivers, Technology, and Effects.Chemical reviews · 2025Review
- High-Precision, Low-Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain-to-Brain Interfaces.Exploration (Beijing, China) · 2025Article
- Chronic, Battery-Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025Article
- Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing.Biosensors · 2025Review
- In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025Article
- Advancing glassy carbon microelectrode arrays for neurochemical sensing: impact of double pyrolysis on structure and function.Frontiers in bioengineering and biotechnology · 2025Article
- Improving Sensitivity and Longevity of In Vivo Glutamate Sensors with Electrodeposited NanoPt.ACS applied materials & interfaces · 2024Article
- Computational analysis of electrode structure and configuration for efficient and localized neural stimulation.Biomedical engineering letters · 2024Article
- Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation.Nature nanotechnology · 2024Article
- A Comparative Study on the Effect of Substrate Structure on Electrochemical Performance and Stability of Electrodeposited Platinum and Iridium Oxide Coatings for Neural Electrodes.Micromachines · 2023Article
- Enhanced Proliferation and Differentiation of Human Osteoblasts by Remotely Controlled Magnetic-Field-Induced Electric Stimulation Using Flexible Substrates.ACS applied materials & interfaces · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Electrical microstimulation has enabled partial restoration of vision, hearing, movement, somatosensation, as well as improving organ functions by electrically modulating neural activities. However, chronic microstimulation is faced with numerous challenges. The implantation of an electrode array into the neural tissue triggers an inflammatory response, which can be exacerbated by the delivery of electrical currents. Meanwhile, prolonged stimulation may lead to electrode material degradation., which can be accelerated by the hostile inflammatory environment. Both material degradation and adverse tissue reactions can compromise stimulation performance over time. For stable chronic electrical stimulation, an ideal microelectrode must present 1) high charge injection limit, to efficiently deliver charge without exceeding safety limits for both tissue and electrodes, 2) small size, to gain high spatial selectivity, 3) excellent biocompatibility that ensures tissue health immediately next to the device, and 4) stable in vivo electrochemical properties over the application period. In this review, the challenges in chronic microstimulation are described in detail. To aid material scientists interested in neural stimulation research, the in vitro and in vivo testing methods are introduced for assessing stimulation functionality and longevity and a detailed overview of recent advances in electrode material research and device fabrication for improving chronic microstimulation performance is provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.