Evidence map›Paper›PMID 34028986›Full record

ArticlePediatric blood & cancer2021

A safety and feasibility trial of

Brian D Weiss, Gregory Yanik, Arlene Naranjo, Fan F Zhang, Wendy Fitzgerald, Barry L Shulkin, Marguerite T Parisi, Heidi Russell, Stephan Grupp, Luke Pater and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Pediatric blood & cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Development of novel GPC2-directed radiotheranostics and CAR T cell therapy for neuroblastoma.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Phase I Study ofJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  9. Article
  10. Review
  11. Molecular regulation and therapeutic targeting ofFrontiers in cell and developmental biology · 2025
    Review
  12. Review
  13. Article
  14. Patterns of recurrence after radiotherapy for high-risk neuroblastoma: Implications for radiation dose and field.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2024
    Article
  15. Review
  16. Article
  17. Review
  18. The Impact ofChildren (Basel, Switzerland) · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 2 countries.

Brian D WeissCincinnati Children's Hospital, University of Cincinnati School of Medicine Cincinnati, Ohio.ORCID 0000-0001-5154-3134
Gregory YanikCS Mott Children's Hospital, University of Michigan School of Medicine, Ann Arbor, Michigan.
Arlene NaranjoChildren's Oncology Group Statistics and Data Center, University of Florida, Gainesville, Florida.
Fan F ZhangChildren's Oncology Group Statistics and Data Center, Monrovia, California.ORCID 0000-0002-1606-7766
Wendy FitzgeraldChildren's National Health System, District of Columbia, Washington.
Barry L ShulkinSt. Jude Children's Research Hospital, University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0003-4784-7914
Marguerite T ParisiSeattle Children's Hospital, Seattle, Washington.
Heidi RussellTexas Children's Cancer and Hematology Centers, Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-6394-4709
Stephan GruppChildren's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Luke PaterCincinnati Children's Hospital, University of Cincinnati School of Medicine Cincinnati, Ohio.
Peter MatteiChildren's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Yael MosseChildren's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Hollie A LaiChildren's Hospital of Orange County, Orange, California.
Jason A JarzembowskiMidwest Children's Cancer Center, Milwaukee, Wisconsin.
Hiroyuki ShimadaLucille Packards Children's Hospital, Palo Alto, California.
Judith G VillablancaChildren's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.ORCID 0000-0002-7174-669X
Roger GillerChildren's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.
Rochelle BagatellChildren's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Julie R ParkSeattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington.
Katherine K MatthayUCSF Benioff Children's Hospital, University of California San Francisco School of Medicine, San Francisco, California.ORCID 0000-0002-0146-2499
Children's Hospital of Philadelphia · USChildren's Oncology Group · CHCincinnati Children's Hospital Medical Center · USSeattle Children's Hospital · USBaylor College of Medicine · USChildren's Hospital Colorado · USChildren's Hospital of Orange County · USChildren's Hospital of Wisconsin · USChildren's National · USLucile Packard Children's Hospital · USSt. Jude Children's Research Hospital · USUniversity of California, San Francisco · USUniversity of Michigan · USUniversity of Southern California · US

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899
6 · The paper itself

Abstract

introduction

methodsPatients with MIBG-avid high-risk neuroblastoma were eligible. After the first two patients to receive protocol therapy developed severe sinusoidal obstruction syndrome (SOS), the trial was re-designed to include an

resultsFifty-nine of 68 patients (86.8%) who completed induction chemotherapy received

conclusionThis pilot trial demonstrated feasibility and tolerability of administering

Indexed as

3-IodobenzylguanidineNeuroblastomaBusulfanFeasibility StudiesHumansIodine RadioisotopesNeoplasm Recurrence, LocalPilot Projects3-IodobenzylguanidineBusulfanIodine RadioisotopesBu/Melhigh riskMIBGneuroblastoma

Identifiers

PMID34028986
PMCPMC9150928
OpenAlexW3164753345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.