ArticleJournal of applied clinical medical physics2021
Dosimetry with a clinical linac adapted to FLASH electron beams.
Article in Journal of applied clinical medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A systematic review of electron FLASH dosimetry and beam control mechanisms utilized with modified non-clinical LINACs.Journal of applied clinical medical physics · 2025Pooled it
- Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.Medical physics · 2026Article
- Article
- A preclinical setup for FLASH radiotherapy beam delivery at isocenter using downstream electron scattering.Journal of applied clinical medical physics · 2026Article
- Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator.PloS one · 2026Article
- Electron and proton FLASH beam dosimetry using unified alanine, EBT-XD, and HD-V2 Gafchromic film dosimeters.Medical physics · 2025Article
- Characterization of a commercial plastic scintillator for electron FLASH dosimetry.Journal of applied clinical medical physics · 2024Article
- Initial experience with an electron FLASH research extension (FLEX) for the Clinac system.Journal of applied clinical medical physics · 2024Article
- Clinical Linear Accelerator-Based Electron FLASH: Pathway for Practical Translation to FLASH Clinical Trials.International journal of radiation oncology, biology, physics · 2023Article
- Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps.International journal of radiation oncology, biology, physics · 2023Review
- FLASH Radiotherapy and the Use of Radiation Dosimeters.Cancers · 2023Review
- Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry.Medical physics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess dosimetric properties and identify required updates to commonly used protocols (including use of film and ionization chamber) pertaining to a clinical linac configured into FLASH (ultra-high dose rate) electron mode.
methodsAn 18MV photon beam of a Varian iX linac was converted to FLASH electron beam by replacing the target and the flattening filter with an electron scattering foil. The dose was prescribed by entering the MUs through the console. Fundamental beam properties, including energy, dose rate, dose reproducibility, field size, and dose rate dependence on the SAD, were examined in preparation for radiobiological experiments. Gafchromic EBT-XD film was evaluated for usability in measurements at ultra-high dose rates by comparing the measured dose to the inverse square model. Selected previously reported models of chamber efficiencies were fitted to measurements in a broad range of dose rates.
resultsThe performance of the modified linac was found adequate for FLASH radiobiological experiments. With exception of the increase in the dose per MU on increase in the repetition rate, all fundamental beam properties proved to be in line with expectations developed with conventional linacs. The field size followed the theorem of similar triangles. The highest average dose rate (2 × 10
conclusionDosimetric measurements were performed to characterize a linac converted to FLASH dose rates. Gafchromic EBT-XD film and dose rate-corrected cc13 ionization chamber were demonstrated usable at FLASH dose rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.