Evidence map›Paper›PMID 34028851›Full record

ArticleThe International journal of eating disorders2021

The diagnosis of avoidant restrictive food intake disorder in the presence of gastrointestinal disorders: Opportunities to define shared mechanisms of symptom expression.

Julia K Nicholas, Miranda A L van Tilburg, Ilana Pilato, Savannah Erwin, Alannah M Rivera-Cancel, Lindsay Ives, Marsha D Marcus, Nancy L Zucker

Open access · greenAbstract read
In one paragraph

Article in The International journal of eating disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Avoidant-Restrictive Food Intake Disorder in Patients With Gastrointestinal Disorders: A Systematic Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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  19. Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Julia K NicholasDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0001-7218-5719
Miranda A L van TilburgCollege of Pharmacy & Health Sciences, Campbell University, Buies Creek, North Carolina, USA.
Ilana PilatoDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Savannah ErwinDepartment of Psychology and Neuroscience, Duke University, Durham, North Carolina, USA.
Alannah M Rivera-CancelDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Lindsay IvesDepartment of Psychology and Neuroscience, Duke University, Durham, North Carolina, USA.
Marsha D MarcusDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Nancy L ZuckerDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Duke University · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · US

Funding

SCH: INT: Computational Tools for Avoidaint/Restrictive Food Intake Disorder R01MH122370 · NIMH · DUKE UNIVERSITY · PI SAPIRO, GUILLERMO R, ZUCKER, NANCY L · 2019 to 2021
$860k
NIMH NIH HHS R01 MH122370
6 · The paper itself

Abstract

objectiveIndividuals with a gastrointestinal (GI) disorder often alter their diet to manage GI symptoms, adding complexity to understanding the diverse motivations contributing to food avoidance/restriction. When a GI disorder is present, the DSM-5 states that Avoidant/Restrictive Food Intake Disorder (ARFID) can be diagnosed only when eating disturbance exceeds that expected. There is limited guidance to make this determination. This study attempts to address this gap by characterizing the presentation of ARFID in adults with and without a self-reported GI disorder.

methodParticipants were 2,610 adults ages 18-44 who self-identified as "picky eaters." Participants reported on motivations for food avoidance, affective experiences towards food, and perceived impairment. Responses were compared across four groups: GI issues and likely ARFID (L-ARFID/GI), L-ARFID-only, GI-only, and No-ARFID/No-GI.

resultsGroups with a GI disorder (L-ARFID/GI, GI-only) reported more fear of aversive consequences of eating than those without a GI disorder, while groups with L-ARFID (L-ARFID, L-ARFID/GI) evidenced significantly greater sensory aversion to food and indifference to food or eating, negative emotional reactions to food and overall disgust sensitivity, and eating related impairment. DISCUSSION: Consideration of the interplay of a GI disorder with ARFID can add precision to case conceptualization. Food avoidance may be attempts to manage fears of aversive consequences that are augmented by a history of GI symptoms, while sensory aversions and negative emotional reactions towards foods may be more elevated in ARFID. These findings emphasize the need to consider an ARFID diagnosis in patients with GI disorders to optimize care.

Indexed as

Avoidant Restrictive Food Intake DisorderDisgustFeeding and Eating DisordersGastrointestinal DiseasesAdolescentAdultDiagnostic and Statistical Manual of Mental DisordersHumansYoung Adultavoidant restrictive food intake disorderdietary modificationdisgustfood neophobiafunctional gastrointestinal disordersgastrointestinal disorders

Identifiers

PMID34028851
PMCPMC8352498
OpenAlexW3164173334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.