ArticleAging clinical and experimental research2021
Nutritional status mediates the relationship between sarcopenia and cognitive impairment: findings from the WCHAT study.
Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Meta-analysis on the interrelationship between sarcopenia and mild cognitive impairment, Alzheimer's disease and other forms of dementia.Journal of cachexia, sarcopenia and muscle · 2024Pooled it
- A systematic review and meta-analysis of the prevalence and correlation of mild cognitive impairment in sarcopenia.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Article
- Association of Sarcopenia With Cognitive Function in Patients With Parkinson's Disease: A Cross-Sectional Study.Brain and behavior · 2026Article
- A 6-year cohort study of the associations of body mass index, waist circumference, and waist-hip ratio with cognitive impairment in Chinese elderly.Frontiers in psychology · 2026Article
- The mediating effect of arteriosclerosis on the relationship between sarcopenia and cognitive impairment: a retrospective analysis.Frontiers in medicine · 2026Article
- Development and Expert Consensus of an Evidence-Based Strategy to Prevent Postoperative Delirium in Malnourished Cancer Patients.Journal of multidisciplinary healthcare · 2026Article
- Joint trajectories of objective physical function and cognition and risk of incident dementia: a population-based cohort study.Frontiers in psychiatry · 2026Article
- Nutritional status mediates the relationship between depression and mild cognitive impairment among Chinese community-dwelling older adults.Frontiers in psychiatry · 2026Article
- Associations of Nutritional Health Risk With Cognitive Function in Older Korean Adults: The Mediating Roles of Lower Body Strength and Depression.Geriatrics & gerontology international · 2025Article
- Associations Between Poor Appetite, Sarcopenia, and Cognitive Function in Community-dwelling Malaysian Older Adults.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2025Article
- Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes.Frontiers in aging neuroscience · 2025Article
- Mild cognitive impairment predicts the onset of Sarcopenia: a longitudinal analysis from the English Longitudinal Study on Ageing.Aging clinical and experimental research · 2024Article
- The longitudinal bidirectional association between sarcopenia and cognitive function in community-dwelling older adults: Findings from the China Health and Retirement Longitudinal Study.Journal of global health · 2023Article
- Neurofilament-light chains (NF-L), a biomarker of neuronal damage, is increased in patients with severe sarcopenia: results of the SarcoPhAge study.Aging clinical and experimental research · 2023Article
- One-year change in sarcopenia was associated with cognitive impairment among haemodialysis patients.Journal of cachexia, sarcopenia and muscle · 2023Article
- Screening efficacy of PhA and MNA-SF in different stages of sarcopenia in the older adults in community.BMC geriatrics · 2023Article
- Physical Activity Mediates the Relationship Between Sarcopenia and Cognitive Function Among Older Adults in Nursing Homes.Clinical interventions in aging · 2023Article
- Association between body mass index and cognitive impairment in Chinese older adults.Frontiers in public health · 2023Article
- Sarcopenia and nervous system disorders.Journal of neurology · 2022Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSarcopenia is associated with cognitive impairment in older adults. However, the underlying mechanisms are not fully understood.
aimTo explore the mediating role of nutritional status in the relationship between sarcopenia and cognitive impairment.
methodsThree thousand eight hundred and ten participants (mean age 61.94 ± 8.01 years) from the West China Health and Aging Trend (WCHAT) study were included. We defined sarcopenia using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Cognitive status and nutritional status were measured using the Short Portable Mental Status Questionnaire (SPMSQ) and the Mini Nutritional Assessment Short Form (MNA-SF). Relationships between sarcopenia, nutritional status, and cognitive function were explored using multiple linear regression. Two mediation models were generated to examine whether nutritional status mediates the association between sarcopenia and cognitive function using PROCESS macro version 3.5.
resultsThe study involved 3147 (82.6%) non-sarcopenic, 387 (10.2%) sarcopenic, and 276 (7.2%) severely sarcopenic individuals. In mediation model 1, sarcopenia (β = 0.208, 95% CI 0.072 to 0.344, P = 0.0028) was significantly associated with cognitive impairment, and nutritional status mediated this association (indirect effect = 0.162, bootstrap 95% CI 0.116 to 0.212). Mediation model 2 indicated that nutritional status exhibited a full mediating effect regarding the association between sarcopenia and cognitive impairment (indirect effect = 0.131, bootstrap 95% CI: 0.08 to 0.188; direct effect = 0.046, bootstrap 95% CI - 0.115 to 0.21) and a partial mediating effect regarding the association between severe sarcopenia and cognitive impairment (indirect effect = 0.21, bootstrap 95% CI: 0.143 to 0.283; direct effect = 0.476, bootstrap 95% CI: 0.234-0.724).
conclusionsThe relationship between sarcopenia and cognitive impairment was significantly mediated by nutritional status. Early nutritional interventions may prevent cognitive decline in sarcopenic older adults.
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