ArticleWorld journal of urology2021
The prognostic effect of metastasis patterns on overall survival in patients with distant metastatic bladder cancer: a SEER population-based analysis.
Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Epigenomics-Guided Multi-Omics Integration Uncovers a Lipid-Metabolic Signature with Translational Utility in Bladder Cancer.Computational and structural biotechnology journal · 2026Article
- The Impact of the Localization of Metastasis in Bladder Cancer Patients with Recurrence After Cystectomy.Cancers · 2025Article
- Development and Validation of a Competitive Risk Model in Elderly Patients with Transitional Cell Bladder Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Development and validation of a risk prediction model for distant metastasis in muscle-invasive bladder cancer: a retrospective study integrating SEER data with external validation cohort and biomarker analysis.Frontiers in oncology · 2025Article
- m6A reader IGF2BP2 promotes M2 macrophage polarization and malignant biological behavior of bladder cancer by stabilizing NRP1 mRNA expression.BMC urology · 2024Article
- Metastatic Bladder Urothelial Carcinoma Masquerading as Myositis.Journal of medical cases · 2024Article
- ACAT1 promotes proliferation and metastasis of bladder cancer via AKT/GSK3β/c-Myc signaling pathway.Journal of Cancer · 2024Article
- Predictive nomograms for risk and prognostic factors in metastatic bladder cancer: a population-based study.Translational cancer research · 2023Article
- Do Histology and Primary Tumor Location Influence Metastatic Patterns in Bladder Cancer?Current oncology (Toronto, Ont.) · 2023Article
- Letter to the editor for the article "Molecular urothelial tumor cell subtypes remain stable during metastatic evolution".World journal of urology · 2023Article
- Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions.Oncogenesis · 2023Review
- Development and validation a model for predicting overall survival of bladder cancer with lung metastasis: a population-based study.European journal of medical research · 2023Article
- Identification of N7-methylguanosine-related lncRNAs for the risk stratification of hepatocellular carcinoma.Journal of gastrointestinal oncology · 2023Article
- Web-Based Nomograms for Overall Survival and Cancer-Specific Survival of Bladder Cancer Patients with Bone Metastasis: A Retrospective Cohort Study from SEER Database.Journal of clinical medicine · 2023Article
- Article
- Prognostic Significance of Organ-Specific Metastases in Patients with Metastatic Upper Tract Urothelial Carcinoma.Journal of clinical medicine · 2022Article
- Radical cystectomy and chemotherapy on plasmacytoid variant bladder urothelial carcinoma.World journal of urology · 2022Article
- Distant metastasis without regional progression in non-muscle invasive bladder cancer: case report and pooled analysis of literature.World journal of surgical oncology · 2022Article
- Effects of Different Organ Metastases on the Prognosis of Stage IV Urothelial Carcinoma of the Bladder.Journal of oncology · 2022Article
- Predictive nomograms for early death in metastatic bladder cancer.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundThe prognostic impact of different distant metastases pattern in bladder cancer is unexplored still now. The aim of this study is to investigate the impact of different distant metastases pattern on the survival of patients with stage IV bladder cancers.
methodsA SEER analysis was performed and the overall survival was calculated by the Kaplan-Meier method. Multivariable Cox regression models were used to further analyze survival outcome and other prognostic factors.
resultsA total of 90,382 eligible cases were retrieved in the Surveillance, Epidemiology, and End Results database. Among these patients, stage of IV bladder cancer accounted for 7.03% (6354/90382) at initial diagnosis. Patients who suffered metastasis occupied 35.51% (2256/6354). Comparing with other three single metastases, the patients with liver metastasis exhibited worst OS whose mean of survival was 7.118 months. Multivariate analysis with Cox hazard regression model showed that metastatic site was an independent prognostic factor of OS in patients with single metastasis (P < 0.05). The results of univariate survival analysis showed that metastatic pattern, sex, age, race, tumor stage, N-classification, differentiated grade, histological type, chemotherapy, radiotherapy and insurance status were not significantly correlated with overall survival of patients with two or three metastatic sites (all, P > 0.05).
conclusionsBone was the most common site of single metastasis for bladder cancers. Patients with liver metastasis had worse survival outcome comparing with other three distant metastases. Knowledge of these differences in metastatic patterns might help to better guide pre-treatment evaluation of bladder cancer and make determination regarding curative-intent interventions.
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