Evidence map›Paper›PMID 34028573›Full record

ArticleInternational urogynecology journal2022

Changes in cardinal ligament length and curvature with parity and prolapse and their relation to level III hiatus measures.

Wenjin Cheng, Mary Duarte Thibault, Luyun Chen, John O L DeLancey, Carolyn W Swenson

Open access · greenAbstract read
In one paragraph

Article in International urogynecology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wenjin ChengDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. wenjinc525@yahoo.com.ORCID http://orcid.org/0000-0003-1465-5887
Mary Duarte ThibaultDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Luyun ChenDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
John O L DeLanceyDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Carolyn W SwensonDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Which pelvic floor defects cause stress incontinence?P50HD044406 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DELANCEY, JOHN O.L. · 2002 to 2017
$17.1M
University of Michigan WRHR Career Development ProgramK12HD065257 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FENNER, DEE ELLEN · 2010 to 2019
$3.4M
Using a mechanistic classification scheme to identify the causes of anterior vaginal wall prolapse and develop a validated surgical planning systemR01HD094954 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, LUYUN · 2018 to 2020
$935k
NCATS NIH HHS UL1 TR002240NIA NIH HHS AG024824NIA NIH HHS P30 AG024824NICHD NIH HHS K12 HD065257NICHD NIH HHS P50 HD044406NICHD NIH HHS R01 HD094954
6 · The paper itself

Abstract

introduction and hypothesisTest the hypotheses that (1) cardinal ligament (CL) straightening and lengthening occur with parity and prolapse, (2) CL straightening occurs before lengthening, and (3) CL length is correlated with level III measures.

methodsWe performed a secondary analysis of MRIs from women in three groups: (1) nulliparous with normal support, (2) parous with normal support, and (3) uterine prolapse (POP-Q point C > - 4 and Ba > 1 cm). The 3D stress MRI images at rest and maximal Valsalva were analyzed. CLs were traced from their origin to cervico-vaginal insertions. Curvature ratio was calculated as curved length/straight length. Level III measures included urogenital hiatus (UGH), levator hiatus (LH), and levator bowl volume (LBV), and their correlations with CL length were calculated.

resultsTen women were included in each group. Compared to the nulliparous group, CL length was 18% longer in parous controls (p = .04) and 59% longer with prolapse (p < .01) at rest, while at Valsalva, CL length was 10% longer in parous controls (p = .21) and 49% longer with prolapse (p < .01). Curvature ratios showed 18% more straightening in women with prolapse compared to parous controls (p < .01). Curved CL length and level III measures were moderately to strongly correlated: UGH (rest: R = 0.68, p < .01; Valsalva: R =0.80, p < .01), LH (rest: R = 0.60, p < .01; Valsalva: R = 0.78, p < .01), and LBV (rest: R = 0.71, p < .01; Valsalva: R =0.89, p < .01).

conclusionOur findings suggest that the CLs undergo three times as much lengthening with prolapse as with parity; however, straightening only occurs with prolapse. Strong correlations exist between level I and level III support.

Indexed as

Pelvic FloorPelvic Organ ProlapseFemaleHumansLigamentsParityPregnancyValsalva ManeuverCardinal ligament curvatureCardinal ligament lengthLevel III supportLevel I supportProlapse

Identifiers

PMID34028573
PMCPMC10519143
OpenAlexW3165597456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.