Evidence map›Paper›PMID 34028356›Full record

ArticleeLife2021

Design principles of the ESCRT-III Vps24-Vps2 module.

Sudeep Banjade, Yousuf H Shah, Shaogeng Tang, Scott D Emr

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Vps60 initiates alternative ESCRT-III filaments.The Journal of cell biology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Bro1 family proteins harmonize cargo sorting with vesicle formation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
    Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sudeep BanjadeWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0002-5920-891X
Yousuf H ShahWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.
Shaogeng TangDepartment of Biochemistry, Stanford University, Stanford, United States.ORCID 0000-0002-3904-492X
Scott D EmrWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0002-5408-6781

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

ESCRT-III polymerization is required for all endosomal sorting complex required for transport (ESCRT)-dependent events in the cell. However, the relative contributions of the eight ESCRT-III subunits differ between each process. The minimal features of ESCRT-III proteins necessary for function and the role for the multiple ESCRT-III subunits remain unclear. To identify essential features of ESCRT-III subunits, we previously studied the polymerization mechanisms of two ESCRT-III subunits Snf7 and Vps24, identifying the association of the helix-4 region of Snf7 with the helix-1 region of Vps24 (Banjade et al., 2019a). Here, we find that mutations in the helix-1 region of another ESCRT-III subunit Vps2 can functionally replace Vps24 in

Indexed as

Endosomal Sorting Complexes Required for TransportGene Expression Regulation, FungalMutationProtein BindingProtein Conformation, alpha-HelicalProtein Interaction Domains and MotifsProtein TransportSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsStructure-Activity RelationshipDID4 protein, S cerevisiaeEndosomal Sorting Complexes Required for TransportSaccharomyces cerevisiae ProteinsVps24 protein, S cerevisiaebiochemistrycell biologychemical biologyESCRT-IIImultivesicular bodiespolymerizationprotein traffickingS. cerevisiae

Identifiers

PMID34028356
PMCPMC8143795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.