Evidence map›Paper›PMID 34028071›Full record

ReviewMass spectrometry reviews2023

The development and application of matrix assisted laser desorption electrospray ionization: The teenage years.

Michael Caleb Bagley, Kenneth P Garrard, David C Muddiman

Open access · greenAbstract readReview
In one paragraph

Review in Mass spectrometry reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Deep Ultraviolet Laser Ablation Electrospray Ion Mobility Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Mass Spectrometry Imaging.Analytical chemistry · 2025
    Review
  15. Article
  16. Article
  17. Feasibility of IR-MALDESI Mass Spectrometry Imaging of PFAS.Journal of mass spectrometry : JMS · 2025
    Article
  18. Article
  19. In-depth characterization ofResearch and practice in thrombosis and haemostasis · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael Caleb BagleyFTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.
Kenneth P GarrardFTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.
David C MuddimanFTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA.
North Carolina State University · US

Funding

Development and Application of New Ionization Methods for Biological Mass SpectrometryR01GM087964 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MUDDIMAN, DAVID C. · 2010 to 2025
$4.7M
NIGMS NIH HHS R01 GM087964
6 · The paper itself

Abstract

In the past 15 years, ambient ionization techniques have witnessed a significant incursion into the field of mass spectrometry imaging, demonstrating their ability to provide complementary information to matrix-assisted laser desorption ionization. Matrix-assisted laser desorption electrospray ionization is one such technique that has evolved since its first demonstrations with ultraviolet lasers coupled to Fourier transform-ion cyclotron resonance mass spectrometers to extensive use with infrared lasers coupled to orbitrap-based mass spectrometers. Concurrently, there have been transformative developments of this imaging platform due to the high level of control the principal group has retained over the laser technology, data acquisition software (RastirX), instrument communication, and image processing software (MSiReader). This review will discuss the developments of MALDESI since its first laboratory demonstration in 2005 to the most recent advances in 2021.

Indexed as

LasersSpectrometry, Mass, Electrospray IonizationSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationambient ionizationdirect analysisFTMSIR lasersMALDESImass spectrometry imagingMSiReader

Identifiers

PMID34028071
PMCPMC11609267
OpenAlexW3165630819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.