Evidence map›Paper›PMID 34027982›Full record

ArticleThe Journal of experimental biology2021

Algorithms underlying flexible phototaxis in larval zebrafish.

Alex B Chen, Diptodip Deb, Armin Bahl, Florian Engert

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alex B ChenDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-3950-4460
Diptodip DebJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Armin BahlDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0001-7591-5860
Florian EngertDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Harvard University · USHoward Hughes Medical Institute · US

Funding

Zooming into the fish's brain-What is really going on! Connectomics analysis of larval zebrafish.U19NS104653 · NINDS · HARVARD UNIVERSITY · PI Jeff W Lichtman · 2017 to 2026
$39.4M
Parallelized Imaging and Automated Analysis of Zebrafish Assays with a Gigapixel MicroscopeR44OD024879 · OD · RAMONA OPTICS, INC. · PI HARFOUCHE, MARK · 2018 to 2022
$3.5M
High-Resolution, Parallelized Imaging of Freely Swimming Zebrafish with a Gigapixel MicroscopeR43OD024879 · OD · RAMONA OPTICS, INC. · PI HARFOUCHE, MARK, HORSTMEYER, ROARKE · 2017 to 2017
$225k
NIH HHS R43 OD024879NIH HHS R44 OD024879NINDS NIH HHS U19 NS104653
6 · The paper itself

Abstract

To thrive, organisms must maintain physiological and environmental variables in suitable ranges. Given that these variables undergo constant fluctuations over varying time scales, how do biological control systems maintain control over these values? We explored this question in the context of phototactic behavior in larval zebrafish. We demonstrate that larval zebrafish use phototaxis to maintain environmental luminance at a set point, that the value of this set point fluctuates on a time scale of seconds when environmental luminance changes, and that it is determined by calculating the mean input across both sides of the visual field. These results expand on previous studies of flexible phototaxis in larval zebrafish; they suggest that larval zebrafish exert homeostatic control over the luminance of their surroundings, and that feedback from the surroundings drives allostatic changes to the luminance set point. As such, we describe a novel behavioral algorithm with which larval zebrafish exert control over a sensory variable.

Indexed as

PhototaxisZebrafishAlgorithmsAnimalsLarvaVision, OcularAllostatic controlBehavioral trackingHomeostasisLarval zebrafishLuminance adaptationPhototaxis

Identifiers

PMID34027982
PMCPMC8180250
OpenAlexW3165031986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.