Evidence map›Paper›PMID 34027702›Full record

Trial reportIntegrative cancer therapies

Attention Dysregulation in Breast Cancer Patients Following a Complementary Alternative Treatment Routine: A Double-Blind Randomized Trial.

Talya Dolev, Merav Ben-David, Ilanit Shahadi, Yaakov Freed, Salman Zubedat, Shlomit Aga-Mizrachi, Zev Brand, Shira Galper, Galia Jacobson, Avi Avital

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02890316 nacompletednot on this map

Cognitive and Emotional Assessment of Fatigue During Radiotherapy for Breast Cancer With and Without Homeopathy Treatment

TypeinterventionalSponsorSheba Medical CenterRan2016 to 2018Enrolled64ConditionsBreast CancerArmsHomeopathy remedy, Radiation as adjuvant therapy for breast cancer
NCT05833165 recruitingnot on this map

Feasibility of Integrating Homeopathic Approach in a Comprehensive Cancer Center

TypeobservationalSponsorRambam Health Care CampusRan2023 to 2028Enrolled250ConditionsCancer, Quality of Life, Complementary Medicine, Integrative MedicineArmsFeasibility of a supportive approach
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Attention Regulation Among Sleep-Deprived Air-Force Pilots.Journal of neuroscience research · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Talya DolevFaculty of Medicine, Technion-Israel Institute of Technology and Emek Medical Center, Haifa, Israel.
Merav Ben-DavidTel-Aviv University, Tel-Aviv, Israel.
Ilanit ShahadiTel-Aviv University, Tel-Aviv, Israel.
Yaakov FreedOncology Institute, Ramat Gan, Israel.
Salman ZubedatFaculty of Medicine, Technion-Israel Institute of Technology and Emek Medical Center, Haifa, Israel.
Shlomit Aga-MizrachiFaculty of Medicine, Technion-Israel Institute of Technology and Emek Medical Center, Haifa, Israel.
Zev BrandFaculty of Medicine, Technion-Israel Institute of Technology and Emek Medical Center, Haifa, Israel.
Shira GalperOncology Institute, Ramat Gan, Israel.
Galia JacobsonOncology Institute, Ramat Gan, Israel.
Avi AvitalFaculty of Medicine, Technion-Israel Institute of Technology and Emek Medical Center, Haifa, Israel.ORCID 0000-0002-0691-153X
Technion – Israel Institute of Technology · ILAlzheimer's Association of Israel · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBreast cancer patients and survivors frequently report fatigue, emotional, and cognitive disturbances, which reduce performance at all levels of occupation and make life quality issues a considerable clinical concern. The aim of this study is to evaluate attention and emotion regulation across radiotherapy period and the possible effects of complementary alternative medicine (CAM).

methodsFifty-seven patients with unilateral breast cancer underwent surgery and systemic chemotherapy before participating in this double-blind randomized study. Two thirds were given CAM (n = 38) while the rest received placebo (carrier only, n = 19). Patients' attention and anxiety were physiologically tested at baseline, 2 and 4 weeks during the radiation period as well as 1-month after the end of radiation session.

resultsBoth groups showed similar levels of anxiety with no significant differences at baseline nor post-radiotherapy. Long-term significant recovery of attention performance was observed in the CAM patients, accompanied by a similar tendency in anxiety level, measured by the eye-blink probability.

conclusionsThis study physiologically validates the attention impairment reported among breast cancer survivors; also, it depicted a beneficial late-effect of a routine CAM on attention dysregulation. The suggested non-invasive physiological measures can physiologically monitor patients' psychological and cognitive well-being as well as evaluate the beneficial effect of CAM in breast cancer patients by assessing their coping ability to support the treatment plan. Thus, the results have potential clinical implications on patients' and survivors' quality of life.

trial registrationNIH, NCT02890316. Registered July 2016, http://www.ClinicalTrials.gov.

Indexed as

Breast NeoplasmsAnxietyAttentionFatigueFemaleHumansQuality of Lifeanxietyattentionbreast cancercomplementary alternative medicinedysregulationemotionfatiguehomeopathyradiotherapy

Identifiers

PMID34027702
PMCPMC8150438
OpenAlexW3164125686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.