Evidence map›Paper›PMID 34027371›Full record

ReviewCJC open2021

Association Between Perioperative Atrial Fibrillation and Long-term Risks of Stroke and Death in Noncardiac Surgery: Systematic Review and Meta-analysis.

Jessica T Huynh, Jeff S Healey, Kevin J Um, Maria E Vadakken, Anand S Rai, David Conen, Pascal Meyre, Jawad H Butt, Hooman Kamel, Seleman J Reza and 7 more

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in CJC open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Perioperative atrial fibrillation after non-cardiac surgery - A narrative review.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Risk Factors for New Onset Atrial Fibrillation during Thyroid Gland Surgery.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Jessica T HuynhDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Jeff S HealeyDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Kevin J UmDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Maria E VadakkenDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Anand S RaiDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
David ConenDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Pascal MeyreDepartment of Cardiology and Cardiovascular Research Institute Basel, University Hospital of Basel, University of Basel, Basel, Switzerland.
Jawad H ButtDepartment of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.
Hooman KamelFeil Family Brain and Mind Research Institute, Department of Neurology, Weill Cornell Medical College, New York, New York, USA.
Seleman J RezaDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Stephanie T NguyenDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Zardasht OqabPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
P J DevereauxDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Kumar BalasubramanianPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Alexander P BenzPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Emilie P Belley-CoteDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
William F McIntyreDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
McMaster University · CAPopulation Health Research Institute · CACopenhagen University Hospital · DKMIND Research Institute · USUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is frequently reported as a complication of noncardiac surgery. It is unknown whether new-onset perioperative AF is associated with an increased risk of stroke and death beyond the perioperative period. We performed a systematic review and meta-analysis to assess the long-term risks of stroke and mortality associated with new-onset perioperative AF after noncardiac surgery.

methodsMEDLINE and EMBASE were searched from inception to March 2020 for studies reporting on the association between perioperative AF and the risk of stroke and death occurring beyond 30 days after noncardiac surgery. Reference screening, study selection, data extraction, and quality assessment were performed in duplicate. Data were pooled using inverse variance-weighted random-effects models and presented as risk ratios (RRs).

resultsFrom 7344 citations, we included 31 studies (3,529,493 patients). The weighted mean incidence of perioperative AF was 0.7%. During a mean follow-up of 28.1 ± 9.4 months, perioperative AF was associated with an increased risk of stroke (1.5 vs 0.9 strokes per 100 patient-years; RR: 2.9, 95% confidence interval [CI]: 2.1-3.9, I

conclusionsPatients who had perioperative AF after noncardiac surgery had a higher long-term risk of stroke and mortality compared with patients who did not. Whether this risk is modifiable with oral anticoagulation therapy should be investigated.

Identifiers

PMID34027371
PMCPMC8134907
OpenAlexW3118401472

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.