Evidence map›Paper›PMID 34027337›Full record

ReviewJHEP reports : innovation in hepatology2021

Defatting strategies in the current era of liver steatosis.

Laura Ioana Mazilescu, Markus Selzner, Nazia Selzner

Open access · goldAbstract readReview
In one paragraph

Review in JHEP reports : innovation in hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A Review of Defatting Strategies for Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Laura Ioana MazilescuAjmera Transplant Program, Toronto General Hospital, Ontario, Canada.
Markus SelznerAjmera Transplant Program, Toronto General Hospital, Ontario, Canada.
Nazia SelznerAjmera Transplant Program, Toronto General Hospital, Ontario, Canada.
Toronto General Hospital · CAEssen University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver steatosis is emerging as a major cause of chronic liver disease worldwide, mainly due to the increasing rate of obesity, type 2 diabetes, and metabolic syndrome. Because of the increased incidence of liver steatosis, many organs are currently declined for transplantation despite high demand and waiting list mortality. Defatting strategies have recently emerged as a means of rapidly reducing liver steatosis to expand the pool of available organs. This review summarises advances in defatting strategies in experimental and human models of liver steatosis over the last 20 years.

Indexed as

GDNF, glial cell-line derived neurotrophic factorHFD, high-fat dietHIEC, hepatic endothelial cellsHOPE, hypothermic machine perfusionischemia-reperfusion injuryLDs, lipid dropletsliver transplantationmachine perfusionMacrosteatosisNAFLD, non-alcoholic fatty liver diseaseNAFL, non-alcoholic fatty liverNASH, non-alcoholic steatohepatitisNEsLP, normothermic ex situ machine perfusionPHHs, primary human hepatocytesPPAR, peroxisome proliferator-activated receptorPXR, pregnane X receptorSCS, static cold storageSRS, steatosis reduction supplementsTG, triglyceride

Identifiers

PMID34027337
PMCPMC8121960
OpenAlexW3137209623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.