Evidence map›Paper›PMID 34027313›Full record

ArticleACS applied nano materials2021

Antibody Conjugation of Fluorescent Nanodiamonds for Targeted Innate Immune Cell Activation.

Lorena P Suarez-Kelly, Steven H Sun, Casey Ren, Isaac V Rampersaud, David Albertson, Megan C Duggan, Tiffany C Noel, Nicholas Courtney, Nathaniel J Buteyn, Charles Moritz and 6 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied nano materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  7. NK cell-based tumor immunotherapy.Bioactive materials · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Lorena P Suarez-KellyThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, United States.
Steven H SunDepartment of Surgery, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0002-0173-3762
Casey RenThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0003-2439-1053
Isaac V RampersaudColumbus NanoWorks, Inc., Columbus, Ohio 43212, United States.
David AlbertsonColumbus NanoWorks, Inc., Columbus, Ohio 43212, United States.
Megan C DugganThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, United States.
Tiffany C NoelThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, United States.
Nicholas CourtneyThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, United States.
Nathaniel J ButeynDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, United States.
Charles MoritzColumbus NanoWorks, Inc., Columbus, Ohio 43212, United States.
Lianbo YuDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio 43210, United States.
Vedat O YildizDepartment of Biomedical Informatics, The Ohio State University, Columbus, Ohio 43210, United States.
Jonathan P ButcharDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, United States.
Susheela TridandapaniDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, United States.
Arfaan A RampersaudColumbus NanoWorks, Inc., Columbus, Ohio 43212, United States.
William E CarsonThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute and Department of Surgery, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0001-7024-7533
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USColumbus NanoWorks (United States) · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
TWO SIGNAL REQUIREMENT FOR NATURAL KILLER IMMUNITYP01CA095426 · NCI · OHIO STATE UNIVERSITY · PI MUTHUSAMY, NATARAJAN · 2002 to 2016
$29.6M
Tumor ImmunologyT32CA090223 · NCI · OHIO STATE UNIVERSITY · PI CARSON, WILLIAM E. · 2002 to 2023
$4.1M
Advanced Research Training in Immunology for Surgery Trainees (ARTIST)T32AI106704 · NIAID · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER, Jon R Wisler · 2014 to 2026
$3.5M
NCI NIH HHS P01 CA095426NCI NIH HHS P30 CA016058NCI NIH HHS T32 CA090223NHLBI NIH HHS HHSN268201300031CNIAID NIH HHS T32 AI106704
6 · The paper itself

Abstract

backgroundfluorescent nanodiamonds (FND) are nontoxic, infinitely photostable nanoparticles that emit near-infrared fluorescence and have a modifiable surface allowing for the generation of protein-FND conjugates. FND-mediated immune cell targeting may serve as a strategy to visualize immune cells and promote immune cell activation.

methodsuncoated-FND (uFND) were fabricated, coated with glycidol (gFND), and conjugated with immunoglobulin G (IgG-gFND).

results

conclusionantibody-conjugated FND may serve as immune drug delivery vehicles with "track and trace capabilities" to promote directed antitumor activity and minimize systemic toxicities.

Indexed as

antibody conjugationfluorescent nanodiamondsimmunotherapymonocytesnatural killer cells

Identifiers

PMID34027313
PMCPMC8136585
OpenAlexW3134018100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.