Evidence map›Paper›PMID 34027112›Full record

ArticleClinical and experimental hepatology2021

The association between obstructive sleep apnea and non-alcoholic steatohepatitis: a retrospective nationwide inpatient sample analysis.

Anas Renno, Yousef Abdel-Aziz, Yaseen Alastal, Sadik Khuder, Syed Hasan, Ragheb Assaly, Ali Nawras

Open access · diamondAbstract read
In one paragraph

Article in Clinical and experimental hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Prevalence and Risk Factors of Celiac Disease in Patients With Non-Alcoholic Fatty Liver Disease: A Meta-Analysis.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  2. Article
  3. Obesity and Obstructive Sleep Apnea.Handbook of experimental pharmacology · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anas RennoUniversity of Toledo Medical Center, United States.
Yousef Abdel-AzizUniversity of Toledo Medical Center, United States.
Yaseen AlastalUniversity of Toledo Medical Center, United States.
Sadik KhuderUniversity of Toledo Medical Center, United States.
Syed HasanUniversity of Toledo Medical Center, United States.
Ragheb AssalyUniversity of Toledo Medical Center, United States.
Ali NawrasUniversity of Toledo Medical Center, United States.
University of Toledo Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyThe primary purpose of this study was to assess the association of obstructive sleep apnea (OSA) and non-alcoholic steatohepatitis (NASH) from a large national inpatient sample database. MATERIAL AND

methodsWe conducted a retrospective analysis using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample. OSA and NASH patients were identified using the ICD-10-CM code G47.33 and K75.81. Non-NASH patients (control) were randomly selected and matched by age and gender to each NASH patient in a 4 : 1 ratio. Weighted logistic regression models were used to calculate the association between OSA and NASH in addition to different comorbidities.

resultsA total of 54,169 participants were included in our analysis; 10,740 cases of NASH were matched to 43,429 controls (non-NASH). NASH was significantly higher in the white population (82.12% vs. 76.64%,

conclusionsThis is the first study using the ICD-10-CM code with a specific search code for NASH. Our large population database results emphasize that there is a significant association between OSA and NASH.

Indexed as

metabolic syndromemortalitynon-alcoholic steatohepatitisobstructive sleep apnea

Identifiers

PMID34027112
PMCPMC8122103
OpenAlexW3158917781

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.