Evidence map›Paper›PMID 34027111›Full record

ArticleClinical and experimental hepatology2021

Influence of ursodeoxycholic acid therapy on levels of fibroblast growth factor 21, adiponectin and biochemical parameters in intrahepatic cholestasis of pregnancy.

Michał Kukla, Rafał Kierach, Magdalena Skonieczna, Dorota Hudy, Krzysztof Dąbrowski, Tomasz Menżyk, Aleksandra Derra, Dariusz Boroń, Beniamin Oskar Grabarek

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Predictive and Diagnostic Value of Serum Adipokines in Pregnant Women with Intrahepatic Cholestasis.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michał KuklaDepartment of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland.
Rafał KierachGynecology and Obstetrics Ward District Railway Hospital in Katowice, Poland.
Magdalena SkoniecznaDepartment of Systems Biology and Engineering, Silesian University of Technology, Gliwice, Poland.
Dorota HudyDepartment of Systems Biology and Engineering, Silesian University of Technology, Gliwice, Poland.
Krzysztof DąbrowskiGynecology and Obstetrics Ward District Railway Hospital in Katowice, Poland.
Tomasz MenżykDepartment of Internal Medicine, Gastroenterology and Acute Intoxication, Regional Hospital, Tarnów, Poland.
Aleksandra DerraDepartment of Neurology, Medical Centre of Upper Silesia, Katowice, Poland.
Dariusz BorońDepartment of Histology, Cytophysiology and Embryology in Zabrze, University of Technology, Faculty of Medicine, Katowice, Poland.
Beniamin Oskar GrabarekDepartment of Histology, Cytophysiology and Embryology in Zabrze, University of Technology, Faculty of Medicine, Katowice, Poland.
Silesian University of Technology · PLMedical University of Silesia · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim was to assess whether fibroblast growth factor 21 (FGF-21) and adiponectin influence intrahepatic cholestasis of pregnancy (ICP) pathogenesis and whether ursodeoxycholic acid (UDCA) has an impact on their levels. 50 pregnant women with ICP (ICP PW), 50 with uncomplicated pregnancy (HPW) and 50 healthy nonpregnant women (HW) were included. In ICP PW the first blood sample was drawn at the time of diagnosis, while in HPW it was drawn in the 28

Indexed as

adiponectinbile acidsfibroblast growth factor 21insulin resistanceintrahepatic cholestasis of pregnancyursodeoxycholic acid

Identifiers

PMID34027111
PMCPMC8122093
OpenAlexW3139548892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.