ArticleBioengineering & translational medicine2021
Mesenchymal stem cell-inspired microgel scaffolds to control macrophage polarization.
Article in Bioengineering & translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Photoresponsive Granular Hydrogels Enable Spatiotemporal Control of Matrix Mechanics and MSC Behavior.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- In vitro assays for investigating the immunomodulatory properties of human mesenchymal stromal cells.Stem cell research & therapy · 2026Review
- Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments.Advanced healthcare materials · 2025Review
- Extracellular fluid viscosity regulates human mesenchymal stem cell lineage and function.Science advances · 2025Article
- Microporous annealed particle hydrogels in cell culture, tissue regeneration, and emerging application in cancer immunotherapy.American journal of cancer research · 2025Review
- 3D Culture of MSCs for Clinical Application.Bioengineering (Basel, Switzerland) · 2024Review
- Multiphoton imaging for quantification of mesenchymal stem cell survival and distribution in PEG granular hydrogel scaffolds post-implantation into rat cranial bone defects.Biomedical engineering advances · 2024Article
- Granular Hydrogels for Harnessing the Immune Response.Advanced healthcare materials · 2024Review
- Targeted liposomes for macrophages-mediated pulmonary fibrosis therapy.Drug delivery and translational research · 2024Article
- Encapsulated Mesenchymal Stromal Cells as Cyclic Providers of Immunomodulatory Secretomes: A Living on-Demand Delivery System.Advanced healthcare materials · 2024Article
- Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Spatial Confinement Modulates Macrophage Response in Microporous Annealed Particle (MAP) Scaffolds.Advanced healthcare materials · 2023Article
- Void Volume Fraction of Granular Scaffolds.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- Multisized Photoannealable Microgels Regulate Cell Spreading, Aggregation, and Macrophage Phenotype through Microporous Void Space.Advanced healthcare materials · 2023Article
- Sticking Together: Injectable Granular Hydrogels with Increased Functionality via Dynamic Covalent Inter-Particle Crosslinking.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- 4D Printing of Extrudable and Degradable Poly(Ethylene Glycol) Microgel Scaffolds for Multidimensional Cell Culture.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Macrophage-targeted delivery of siRNA to silenceBioengineering & translational medicine · 2022Article
- Methods to Characterize Granular Hydrogel Rheological Properties, Porosity, and Cell Invasion.ACS biomaterials science & engineering · 2022Article
- Human iPSC-Derived Vascular Smooth Muscle Cells in a Fibronectin Functionalized Collagen Hydrogel Augment Endothelial Cell Morphogenesis.Bioengineering (Basel, Switzerland) · 2021Article
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
There is a desire in regenerative medicine to create biofunctional materials that can control and direct cell function in a precise manner. One particular stem cell of interest, human mesenchymal stem cells (hMSCs), can function as regulators of the immunogenic response and aid in tissue regeneration and wound repair. Here, a porous hydrogel scaffold assembled from microgel subunits was used to recapitulate part of this immunomodulatory behavior. The scaffolds were used to culture a macrophage cell line, while cytokines were delivered exogenously to polarize the macrophages to either a pro-inflammatory (M1) or alternatively activated (M2a) phenotypes. Using a cytokine array, interleukin 10 (IL-10) was identified as one key anti-inflammatory factor secreted by hMSCs in pro-inflammatory conditions; it was elevated (125 ± 25 pg/ml) in pro-inflammatory conditions compared to standard medium (6 ± 10 pg/ml). The ability of hMSC laden scaffolds to reverse the M1 phenotype was then examined, even in the presence of exogenous pro-inflammatory cytokines. Co-culture of M1 and M2 macrophages with hMSCs reduced the secretion of TNFα, a pro-inflammatory cytokine even in the presence of pro-inflammatory stimulatory factors. Next, IL-10 was supplemented in the medium or tethered directly to the microgel subunits; both methods limited the secretion of pro-inflammatory cytokines of encapsulated macrophages even in pro-inflammatory conditions. Cumulatively, these results reveal the potential of biofunctional microgel-based scaffolds as acellular therapies to present anti-inflammatory cytokines and control the immunogenic cascade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.