ArticleBioengineering & translational medicine2021
Ultra-thin, high strength, antibiotic-eluting sutures for prevention of ophthalmic infection.
Article in Bioengineering & translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Drug-Free Ultrasound-Responsive Mechanoluminescent Suture Enables On-Demand Antibacterial Therapy and Enhanced Healing of Infected Wounds.Advanced healthcare materials · 2026Article
- Engineering matrix-embedded dual-drug eluting biodegradable surgical sutures for prophylaxis against surgical site infections.RSC advances · 2026Article
- Sunitinib-eluting thin films for Inhibition of corneal neovascularization.Drug delivery and translational research · 2026Article
- Investigation of antibiotic release from amoxicillin- and clindamycin-impregnated silk and Vicryl suture materials: an in vitro study.BMC oral health · 2026Article
- Ion-paired moxifloxacin nanocrystal formulation improves treatment and prevention of ocular infection.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Antibiotic Action, Drug Delivery, Biodegradability, and Wound Regeneration Characteristics of Surgical Sutures and Cutting-Edge Surgical Suture Manufacturing Technologies.Journal of functional biomaterials · 2025Review
- Drug-Eluting Sutures by Hot-Melt Extrusion: Current Trends and Future Potentials.Materials (Basel, Switzerland) · 2023Review
- Pressure-Spun Fibrous Surgical Sutures for Localized Antibacterial Delivery: Development, Characterization, and In Vitro Evaluation.ACS applied materials & interfaces · 2023Article
- Nanofibers in Ocular Drug Targeting and Tissue Engineering: Their Importance, Advantages, Advances, and Future Perspectives.Pharmaceutics · 2023Review
- Nanofiber-coated, tacrolimus-eluting sutures inhibit post-operative neointimal hyperplasia in rats.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Hyperelastic, shape-memorable, and ultra-cell-adhesive degradable polycaprolactone-polyurethane copolymer for tissue regeneration.Bioengineering & translational medicine · 2022Article
- Electrospun Medical Sutures for Wound Healing: A Review.Polymers · 2022Review
- An ion-paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection.Bioengineering & translational medicine · 2021Article
- Engineering biomaterials to prevent post-operative infection and fibrosis.Drug delivery and translational research · 2021Review
- Article
- Ultra-thin, high strength, antibiotic-eluting sutures for prevention of ophthalmic infection.Bioengineering & translational medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Sutures are applied almost universally at the site of trauma or surgery, making them an ideal platform to modulate the local, postoperative biological response, and improve surgical outcomes. To date, the only globally marketed drug-eluting sutures are coated with triclosan for antibacterial application in general surgery. Loading drug directly into the suture rather than coating the surface offers the potential to provide drug delivery functionality to microsurgical sutures and achieve sustained drug delivery without increasing suture thickness. However, conventional methods for drug incorporation directly into the suture adversely affect breaking strength. Thus, there are no market offerings for drug-eluting sutures, drug-coated, or otherwise, in ophthalmology, where very thin sutures are required. Sutures themselves help facilitate bacterial infection, and antibiotic eye drops are commonly prescribed to prevent infection after ocular surgeries. An antibiotic-eluting suture may prevent bacterial colonization of sutures and preclude patient compliance issues with eye drops. We report twisting of hundreds of individual drug-loaded, electrospun nanofibers into a single, ultra-thin, multifilament suture capable of meeting both size and strength requirements for microsurgical ocular procedures. Nanofiber-based polycaprolactone sutures demonstrated no loss in strength with loading of 8% levofloxacin, unlike monofilament sutures which lost more than 50% strength. Moreover, nanofiber-based sutures retained strength with loading of a broad range of drugs, provided antibiotic delivery for 30 days in rat eyes, and prevented ocular infection in a rat model of bacterial keratitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.