Evidence map›Paper›PMID 34027045›Full record

ArticleMolecular & cellular oncology2021

EPHA2, a promising therapeutic target for hepatocellular carcinoma.

Hao Wang, Wei Qiu

Abstract read
In one paragraph

Article in Molecular & cellular oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hao WangDepartment of Surgery, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
Wei QiuDepartment of Surgery, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.ORCID https://orcid.org/0000-0001-8093-3094

Funding

Molecular mechanisms of focal adhesion kinase in promoting hepatocarcinogenesisR01CA197128 · NCI · LOYOLA UNIVERSITY CHICAGO · PI QIU, WEI · 2015 to 2025
$3.6M
NCI NIH HHS R01 CA197128
6 · The paper itself

Abstract

Identifying critical drivers of oncogenesis and tumor progression is essential for developing effective hepatocellular carcinoma (HCC) therapeutics. Our recent findings has demonstrated that targeting Ephrin Receptor A2 (EPHA2) suppresses HCC initiation and progression by dual inhibition of the Protein Kinase B (AKT) and Signal Transducer and Activator of Transcription 3 (STAT3) signaling.

Indexed as

AKTEPHA2HCCJAK1STAT3

Identifiers

PMID34027045
PMCPMC8128187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.