Evidence map›Paper›PMID 34027016›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study.

Jackie M Poos, Lucy L Russell, Georgia Peakman, Martina Bocchetta, Caroline V Greaves, Lize C Jiskoot, Emma L van der Ende, Harro Seelaar, Janne M Papma, Esther van den Berg and 28 more

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Composite grey matter fingerprints for genetic frontotemporal dementia.Journal of neurology, neurosurgery, and psychiatry · 2026
    Article
  4. Review
  5. Article
  6. Article
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  8. Article
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  10. Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities-focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
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  12. Article
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  15. Review
  16. Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 20 institutions in 10 countries.

Jackie M PoosDepartment of Neurology Erasmus Medical Center Rotterdam the Netherlands.
Lucy L RussellDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK.
Georgia PeakmanDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK.
Martina BocchettaDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK.
Caroline V GreavesDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK.
Lize C JiskootDepartment of Neurology Erasmus Medical Center Rotterdam the Netherlands.
Emma L van der EndeDepartment of Neurology Erasmus Medical Center Rotterdam the Netherlands.
Harro SeelaarDepartment of Neurology Erasmus Medical Center Rotterdam the Netherlands.
Janne M PapmaDepartment of Neurology Erasmus Medical Center Rotterdam the Netherlands.
Esther van den BergDepartment of Neurology Erasmus Medical Center Rotterdam the Netherlands.
Yolande A L PijnenburgDepartment of Neurology Alzheimer Center Location VU University Medical Center Amsterdam Amsterdam the Netherlands.
Barbara BorroniCentre for Neurodegenerative Disorders Department of Clinical and Experimental Sciences University of Brescia Brescia Italy.
Raquel Sanchez-ValleAlzheimer's Disease and Other Cognitive Disorders Unit Neurology Service Hospital Clínic Institut d'Investigacións Biomèdiques August Pi I Sunyer University of Barcelona Barcelona Spain.
Fermin MorenoCognitive Disorders Unit Department of Neurology Donostia University Hospital San Sebastian Gipuzkoa Spain.
Robert LaforceClinique Interdisciplinaire de Mémoire Département des Sciences Neurologiques CHU de Québec Faculté de Médecine Université Laval Quebec Canada.
Caroline GraffCenter for Alzheimer Research, Division of Neurogeriatrics Department of Neurobiology, Care Sciences and Society Bioclinicum Karolinska Institutet Solna Sweden.
Matthias SynofzikDepartment of Neurodegenerative Diseases Hertie-Institute for Clinical Brain Research and Center of Neurology University of Tübingen Tübingen Germany.
Daniela GalimbertiDepartment of Biomedical, Surgical and Dental Sciences University of Milan Milan Italy.
James B RoweDepartment of Clinical Neurosciences Cambridge University Hospitals NHS Trust Medical Research Council Cognition and Brain Sciences Unit University of Cambridge Cambridge UK.
Mario MasellisSunnybrook Health Sciences Centre Sunnybrook Research Institute University of Toronto Toronto Canada.
Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Canada.
Elizabeth FingerDepartment of Clinical Neurological Sciences University of Western Ontario London Canada.
Rik VandenbergheLaboratory for Cognitive Neurology Department of Neurosciences KU Leuven Leuven Belgium.
Alexandre de MedonçaLaboratory of Neurosciences Institute of Molecular Medicine Faculty of Medicine University of Lisbon Lisbon Portugal.
Fabrizio TagliaviniFondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy.
Chris R ButlerNuffield Department of Clinical Neurosciences Medical Sciences Division University of Oxford Oxford UK.
Isabel SantanaUniversity Hospital of Coimbra (HUC) Neurology Service Faculty of Medicine University of Coimbra Coimbra Portugal.
Isabelle Le BerSorbonne Université Institut du Cerveau (ICM) INSERM U1127 CNRS UMR 7225 APHP Hôpital Pitié-Salpêtrière Paris France.
Alex GerhardDivision of Neuroscience and Experimental Psychology Wolfson Molecular Imaging Centre University of Manchester, Manchester UK.
Simon DucharmeDouglas Mental Health University Institute Department of Psychiatry McGill University Montreal Canada.
Johannes LevinNeurologische Klinik und Poliklinik Ludwig-Maximilians-Universität Munich Germany.
Adrian DanekNeurologische Klinik und Poliklinik Ludwig-Maximilians-Universität Munich Germany.
Markus OttoDepartment of Neurology University of Ulm Ulm Germany.
Sandro SorbiDepartment of Neurofarba University of Florence Firenze Italy.
Florence PasquierUniversity of Lille Lille France.
John C van SwietenDepartment of Neurology Erasmus Medical Center Rotterdam the Netherlands.
Jonathan D RohrerDementia Research Centre Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK.
Genetic FTD Initiative, GENF
Erasmus MC · NLUniversity College London · GBLudwig-Maximilians-Universität München · DENational Hospital for Neurology and Neurosurgery · GBAmsterdam UMC Location VUmc · NLAssistance Publique – Hôpitaux de Paris · FRBiogipuzkoa Health Research Institute · ESDon Carlo Gnocchi Foundation · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITInserm · FRKarolinska Institutet · SEMcGill University · CASunnybrook Health Science Centre · CAUK Dementia Research Institute · GBUniversitat de Barcelona · ESUniversität Ulm · DEUniversité Laval · CAUniversity of Brescia · ITUniversity of Cambridge · GBUniversity of Coimbra · PT

Funding

Medical Research Council MC_UU_00024/1Medical Research Council MR/J009482/1Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2Medical Research Council MR/M008525/1Medical Research Council MR/M023664/1Medical Research Council MR/T046015/1
6 · The paper itself

Abstract

introductionWe aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT).

methodsThe FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [

resultsAll symptomatic mutation carrier groups and presymptomatic DISCUSSION: The FCSRT detects presymptomatic deficits in

Indexed as

cognitionepisodic memoryexecutive functionfrontal lobefrontotemporal dementiagenetic disordersneuropsychologytemporal lobevoxel‐based morphometry

Identifiers

PMID34027016
PMCPMC8116844
OpenAlexW3161543087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.