ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease?
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Altered intrinsic ignition dynamics linked to Amyloid-bioRxiv : the preprint server for biology · 2025Article
- The association between cardiorespiratory fitness and resting-state functional connectivity in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Neural correlates of episodic memory in adults with Down syndrome and Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- Selective Impairment of Long-Range Default Mode Network Functional Connectivity as a Biomarker for Preclinical Alzheimer's Disease in People with Down Syndrome.Journal of Alzheimer's disease : JAD · 2022Article
- Altered connectivity of the default mode network in cognitively stable adults with Down syndrome: "Accelerated aging" or a prelude to Alzheimer's disease?Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionMost individuals with Down syndrome (DS) have the neuropathological changes of Alzheimer's disease (AD) by age 40 and will have developed dementia by age 60. Alterations of the intrinsic connectivity of the default mode network (DMN) are associated with AD in the neurotypical population. In this study, we sought to determine whether, and how, connectivity between the hubs of the DMN were altered in cognitively stable adults with DS who did not have evidence of either mild cognitive impairment or AD.
methodsResting state functional MRI scans were collected from 26 healthy adults with DS and 26 healthy age-matched non-DS controls. Nodes comprising the DMN were generated as ROI's (regions of interest) and inter-nodal correlations estimated.
resultsAnalysis of intra-network connectivity of the DMN revealed anterior-posterior DMN dissociation and hyper- and hypo-connectivity, suggesting "accelerated aging" in DS. DISCUSSION: Disruption of the DMN may serve as a prelude for AD in DS.
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