Evidence map›Paper›PMID 34026755›Full record

ArticleFrontiers in cell and developmental biology2021

Cytolethal Distending Toxin Promotes Replicative Stress Leading to Genetic Instability Transmitted to Daughter Cells.

William Tremblay, Florence Mompart, Elisa Lopez, Muriel Quaranta, Valérie Bergoglio, Saleha Hashim, Delphine Bonnet, Laurent Alric, Emmanuel Mas, Didier Trouche and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Cytolethal distending toxin enhancesInfection and immunity · 2026
    Article
  2. Frequent Detection of Abasic Sites andChemical research in toxicology · 2026
    Article
  3. Cytolethal Distending Toxin EnhancesbioRxiv : the preprint server for biology · 2026
    Article
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  17. Microbiota as the unifying factor behind the hallmarks of cancer.Journal of cancer research and clinical oncology · 2023
    Review
  18. Microbiota regulation in constipation and colorectal cancer.World journal of gastrointestinal oncology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

William TremblayToxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Florence MompartToxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Elisa LopezToxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Muriel QuarantaIRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France.
Valérie BergoglioMCD, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France.
Saleha HashimToxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Delphine BonnetDepartment of Internale and Digestive Diseases, Pole Digestif, CHU Toulouse, Paul Sabatier University, Toulouse, France.
Laurent AlricDepartment of Internale and Digestive Diseases, Pole Digestif, CHU Toulouse, Paul Sabatier University, Toulouse, France.
Emmanuel MasIRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France.
Didier TroucheMCD, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse, France.
Julien VignardToxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Audrey FerrandIRSD, Université de Toulouse, INSERM, INRAE, ENVT, UPS, Toulouse, France.
Gladys MireyToxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Anne Fernandez-VidalToxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Université Toulouse III - Paul Sabatier · FRDigestive Health Research Institute · FRÉcole Nationale Vétérinaire de Toulouse · FRToxalim Research Centre in Food Toxicology · FRHôpital des Enfants · FRInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cytolethal distending toxin (CDT) is produced by several Gram-negative pathogenic bacteria. In addition to inflammation, experimental evidences are in favor of a protumoral role of CDT-harboring bacteria such as

Indexed as

cytolethal distending toxinDNA bridgeDNA damagegenetic instabilityhuman colorectal organoidreplicative stress

Identifiers

PMID34026755
PMCPMC8138442
OpenAlexW3160371273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.