Evidence map›Paper›PMID 34026748›Full record

ArticleFrontiers in cell and developmental biology2021

Effect of Age and Sodium Alendronate on Femoral Fracture Repair: Biochemical and Biomechanical Study in Rats.

Luana Mordask Bonetto, Paola Fernanda Cotait de Lucas Corso, Gabrielle Grosko Kuchar, Jennifer Tsi Gerber, Leonardo Fernandes Cunha, Mohammed Elsalanty, João Cesar Zielak, Carla Castiglia Gonzaga, Rafaela Scariot

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Luana Mordask BonettoDepartment of Dentistry, Positivo University, Curitiba, Brazil.
Paola Fernanda Cotait de Lucas CorsoDepartment of Dentistry, Positivo University, Curitiba, Brazil.
Gabrielle Grosko KucharDepartment of Dentistry, Positivo University, Curitiba, Brazil.
Jennifer Tsi GerberDepartment of Dentistry, Positivo University, Curitiba, Brazil.
Leonardo Fernandes CunhaDepartment of Dentistry, Positivo University, Curitiba, Brazil.
Mohammed ElsalantyDepartment of Medical Anatomical Science, Western University of Health Sciences, Pomona, CA, Unioted States.
João Cesar ZielakDepartment of Dentistry, Positivo University, Curitiba, Brazil.
Carla Castiglia GonzagaDepartment of Dentistry, Positivo University, Curitiba, Brazil.
Rafaela ScariotDepartment of Dentistry, Federal University of Parana, Curitiba, Brazil.
Universidade Positivo · BRUniversidade Federal do Paraná · BRWestern University of Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBisphosphonates are drugs widely used to reduce bone resorption, increase bone mineral density and control age-related bone loss. Although there are studies reporting differences in bone structure between young and old adults, it is still difficult to predict changes related to bone aging. The aim of this study was to evaluate the effect of age and sodium alendronate on bone repair of femoral fractures in rats.

methods

resultsThere was no difference in calcium and alkaline phosphatase levels (

conclusionIn short, there was no difference of calcium and alkaline phosphatase during the bone repair process. Age has influence in cross-section and flexural strength. Alendronate showed no association with these factors.

Indexed as

bisphosphonatesbone regenerationfemurfracturerats

Identifiers

PMID34026748
PMCPMC8131822
OpenAlexW3158768570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.