ArticleFrontiers in bioengineering and biotechnology2021
Osteoarthritis-Related Degeneration Alters the Biomechanical Properties of Human Menisci Before the Articular Cartilage.
Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Spatial Investigation of Facet Joint Cartilage Properties Reveals Specific Structure-Function Relationships.JOR spine · 2026Article
- Simulated microgravity models sex differences in knee osteoarthritis through a CD36-regulated mechano-metabolic circuit.Cell communication and signaling : CCS · 2026Article
- Anisotropic wear behavior of meniscus: Influence of cross-shear and loading magnitude.Journal of the mechanical behavior of biomedical materials · 2026Article
- Degenerated meniscus alters knee osteoarthritis-related gene expression in articular chondrocytes through paracrine mechanisms.Scientific reports · 2025Article
- Chitosan/Platelet-Rich Plasma Implants in an Ovine Arthroscopic Model of Meniscus Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- A Geometric Deep Learning Model for Real-Time Prediction of Knee Joint Biomechanics Under Meniscal Extrusion.Annals of biomedical engineering · 2025Review
- Influence of in vitro test conditions on the Biomechanical properties of degenerated human lateral menisci.Journal of orthopaedic surgery and research · 2025Article
- Regenerative potential of nanoenabled collagen-polylactide scaffolds for osteochondral defect repair in rabbits.Frontiers in bioengineering and biotechnology · 2025Article
- Proof-of-concept study of the TriBot: a robot-based test setup for biotribological analyses of curved articular surfaces.Frontiers in bioengineering and biotechnology · 2025Article
- Biomechanical impact of progressive meniscal extrusion on the knee joint: a finite element analysis.Journal of orthopaedic surgery and research · 2024Article
- Short-term response of primary human meniscus cells to simulated microgravity.Cell communication and signaling : CCS · 2024Article
- Exploring the Early Molecular Pathogenesis of Osteoarthritis Using Differential Network Analysis of Human Synovial Fluid.Molecular & cellular proteomics : MCP · 2024Article
- High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging.Quantitative imaging in medicine and surgery · 2024Article
- Mechanical and histological properties of native medial menisci compared to allograph medial menisci in the osteoarthritic knee.Frontiers in bioengineering and biotechnology · 2024Article
- Modulating pentenoate-functionalized hyaluronic acid hydrogel network properties for meniscal fibrochondrocyte mechanotransduction.Journal of biomedical materials research. Part A · 2023Article
- Intraoperative Acoustic Evaluation of Living Human Knee Cartilage-Comparison with Respect to Cartilage Degeneration and Aging.Cartilage · 2023Article
- Relations between Structure/Composition and Mechanics in Osteoarthritic Regenerated Articular Tissue: A Machine Learning Approach.International journal of molecular sciences · 2023Article
- Total Knee Arthroplasty After Meniscectomy Is More Likely in Patients With Bicompartmental or Complex Tears.Arthroscopy, sports medicine, and rehabilitation · 2023Article
- Effect of molecular weight and tissue layer on solute partitioning in the knee meniscus.Osteoarthritis and cartilage open · 2023Article
- Advanced glycation end-product accumulation differs by location and sex in aged osteoarthritic human menisci.Osteoarthritis and cartilage · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An exact understanding of the interplay between the articulating tissues of the knee joint in relation to the osteoarthritis (OA)-related degeneration process is of considerable interest. Therefore, the aim of the present study was to characterize the biomechanical properties of mildly and severely degenerated human knee joints, including their menisci and tibial and femoral articular cartilage (AC) surfaces. A spatial biomechanical mapping of the articulating knee joint surfaces of 12 mildly and 12 severely degenerated human cadaveric knee joints was assessed using a multiaxial mechanical testing machine. To do so, indentation stress relaxation tests were combined with thickness and water content measurements at the lateral and medial menisci and the AC of the tibial plateau and femoral condyles to calculate the instantaneous modulus (IM), relaxation modulus, relaxation percentage, maximum applied force during the indentation, and the water content. With progressing joint degeneration, we found an increase in the lateral and the medial meniscal instantaneous moduli (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.