Evidence map›Paper›PMID 34026625›Full record

ArticleFrontiers in oncology2021

Exome sequencing in BRCA1-2 candidate familias: the contribution of other cancer susceptibility genes

Gabriella Doddato, Floriana Valentino, Annarita Giliberti, Filomena Tiziana Papa, Rossella Tita, Lucia Pia Bruno, Sara Resciniti, Chiara Fallerini, Elisa Benetti, Maria Palmieri and 18 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. The Genetic and Molecular Analyses of Rare Candidate GermlineInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 2 institutions in 1 country.

Gabriella DoddatoMedical Genetics, University of Siena, Siena, Italy.
Floriana ValentinoMedical Genetics, University of Siena, Siena, Italy.
Annarita GilibertiMedical Genetics, University of Siena, Siena, Italy.
Filomena Tiziana PapaMedical Genetics, University of Siena, Siena, Italy.
Rossella TitaGenetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Lucia Pia BrunoMedical Genetics, University of Siena, Siena, Italy.
Sara RescinitiMedical Genetics, University of Siena, Siena, Italy.
Chiara FalleriniMedical Genetics, University of Siena, Siena, Italy.
Elisa BenettiMed Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Maria PalmieriMedical Genetics, University of Siena, Siena, Italy.
Maria Antonietta MencarelliGenetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Alessandra FabbianiMedical Genetics, University of Siena, Siena, Italy.
Mirella BruttiniMedical Genetics, University of Siena, Siena, Italy.
Alfredo OrricoMolecular Diagnosis and Characterization of Pathogenic Mechanisms of Rare Genetic Diseases, Azienda Ospedaliera Universitaria Senese and Clinical Genetics, ASL Toscana SudEst. Ospedale della Misericordia, Grosseto, Italy.
Margherita BaldassarriMedical Genetics, University of Siena, Siena, Italy.
Francesca FavaMedical Genetics, University of Siena, Siena, Italy.
Diego LopergoloMedical Genetics, University of Siena, Siena, Italy.
Caterina Lo RizzoGenetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Vittoria LamacchiaMedical Genetics, University of Siena, Siena, Italy.
Sara MannucciMedical Genetics, University of Siena, Siena, Italy.
Anna Maria PintoGenetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Aurora CurrMedical Genetics, University of Siena, Siena, Italy.
Virginia ManciniUnit of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.
Oncologic Multidisciplinary Team, Azienda Ospedaliera Universitaria Senese
Oncologic Multidisciplinary Team, Azienda Usl Toscana Sud Est
Francesca MariMedical Genetics, University of Siena, Siena, Italy.
Alessandra RenieriMedical Genetics, University of Siena, Siena, Italy.
Francesca ArianiMedical Genetics, University of Siena, Siena, Italy.
University of Siena · ITAzienda Ospedaliera Universitaria Senese · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary Breast and Ovarian Cancer (HBOC) syndrome is a condition in which the risk of breast and ovarian cancer is higher than in the general population. The prevalent pathogenesis is attributable to inactivating variants of the

Indexed as

BRCA1BRCA2cancer susceptibility genesHBOC, ES (Excome Sequencing)

Identifiers

PMID34026625
PMCPMC8139251
OpenAlexW3165689252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.