ReviewWorld journal of methodology2021
Epidemiological link between obesity, type 2 diabetes mellitus and cancer.
Review in World journal of methodology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Metformin for primary prevention of colorectal neoplasms in adenoma-free populations: a systematic review and dose-response meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Review
- Exploring Long-Term Exercise and Fitness Maintenance Using Group Versus Individual Training in a Diverse Group of Breast Cancer Survivors.Healthcare (Basel, Switzerland) · 2026Article
- Effects of Metformin Treatment Against Endometrial Cancer Cells Cultured In Vitro or Grafted into Female Balb/C Nude Mice: Insights into Cell Response and IGF-1R and PI3K/AKT/mTOR Signaling Pathways.Cell biochemistry and biophysics · 2025Article
- Dietary Manipulation on Gut Microbiome in Patients with Diabetes and Colorectal cancer.Current nutrition reports · 2025Review
- Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study.World journal of gastrointestinal oncology · 2025Article
- A Nonlinear Association of Body Mass Index and Fasting Blood Glucose: A Dose-Response Analysis From Fasa Adults Cohort Study (FACS).Health science reports · 2025Article
- Review
- Inflammation-driven mechanisms in endometrial cancer: pathways from inflammatory microenvironment remodeling to immune escape.Frontiers in immunology · 2025Review
- [Causal Relationship Between Components of Metabolic Syndrome and Endometrial Carcinoma].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic.Biomolecules · 2024Review
- Impact of Breast Cancer on Cardiometabolic Health in Spanish Women ≥50 Years with Pre-Existing Type 2 Diabetes Mellitus.Cancers · 2024Article
- The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study.Open medicine (Warsaw, Poland) · 2024Article
- Correlation between High Incidence of Colorectal Neoplastic Polyps and High-risk Adenomas in Patients with Diabetes Mellitus: A Retrospective Study.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Review
- Type 2 Diabetes and Colorectal Cancer Risk.JAMA network open · 2023Article
- Impacts of pre-existing diabetes mellitus on colorectal cancer in a mice model.Cancer medicine · 2023Article
- The Bidirectional Relationship between Periodontal Disease and Diabetes Mellitus-A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Causal associations between site-specific cancer and diabetes risk: A two-sample Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Communicating Native American Cancer Efforts and Resources in the Great Plains.Great Plains research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There exists a complex interaction between obesity, type 2 diabetes mellitus (T2DM) and cancer, and an increase in the incidence of cancer is expected with the growing obesity-diabetes pandemic. The association of cancer with diabetes mellitus and obesity appears to be site-specific, the highest risk being for post-menopausal breast cancer, endometrial cancer, and colorectal cancer. Moreover, there is worsening of hyperglycaemia with the onset of cancer, evidencing a bi-directional link between cancer and diabetes mellitus and the need for monitoring for diabetes in cancer survivors. In this review, we look at the epidemiological evidence from observational studies and Mendelian randomization studies linking obesity, diabetes, and cancer, as well as the complex pathophysiological mechanisms involved, including insulin resistance with associated hyperinsulinaemia, the effect of chronic low-grade inflammation, and the effect of various adipokines that are associated with obesity and T2DM. Additionally, we describe the novel therapeutic strategies, based on their role on the discrete pathophysiological mechanisms involved in the tumourigenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.