ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 104 citations in OpenAlex.
- MicroFace maps microglial morphology remodeling, revealing spatial zones and bifurcated trajectories during brain microinjury recovery.iScience · 2026Article
- Mechanically adaptive materials with tunable stiffness for biomedical devices: Mechanisms, applications, and perspectives.Materials today. Bio · 2026Review
- A Mussel-Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-power dual-channel chamber for high-frequency magnetic neuromodulation.Journal of neural engineering · 2026Article
- PVA:ALG Hybrid Bioink for Biofabrication of 3D Neural Models.ACS omega · 2026Article
- Emerging Triboelectric Nanogenerators for In-Body Implantation.Small methods · 2026Review
- Review
- Sub-400 nanometer-thick skin and environment adaptable organohydrogel nanofilm epidermal electrode.Nature communications · 2025Article
- Bridging circuit modeling and signal analysis to understand the risk of crosstalk contamination in brain recordings.Nature communications · 2025Article
- Article
- Soft Robotics for Parkinson's Disease Supported by Functional Materials and Artificial Intelligence.BME frontiers · 2025Review
- Time series segmentation for recognition of epileptiform patterns recorded via microelectrode arrays in vitro.PloS one · 2025Article
- Multifunctional hydrogel electronics for closed-loop antiepileptic treatment.Science advances · 2024Article
- Topic Editorial on Flexible Electronics.Micromachines · 2024Article
- Self-adaptive rotational electromagnetic energy generation as an alternative to triboelectric and piezoelectric transductions.Communications engineering · 2024Article
- Flexible neural probes: a review of the current advantages, drawbacks, and future demands.Journal of Zhejiang University. Science. B · 2024Review
- Glial scarring around intra-cortical MEA implants with flexible and free microwires inserted using biodegradable PLGA needles.Frontiers in bioengineering and biotechnology · 2024Article
- A snapshot review on materials enabled multimodal bioelectronics for neurological and cardiac research.MRS advances · 2023Article
- Review
- Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurological diseases are a prevalent cause of global mortality and are of growing concern when considering an ageing global population. Traditional treatments are accompanied by serious side effects including repeated treatment sessions, invasive surgeries, or infections. For example, in the case of deep brain stimulation, large, stiff, and battery powered neural probes recruit thousands of neurons with each pulse, and can invoke a vigorous immune response. This paper presents challenges in engineering and neuroscience in developing miniaturized and biointegrated alternatives, in the form of microelectrode probes. Progress in design and topology of neural implants has shifted the goal post toward highly specific recording and stimulation, targeting small groups of neurons and reducing the foreign body response with biomimetic design principles. Implantable device design recommendations, fabrication techniques, and clinical evaluation of the impact flexible, integrated probes will have on the treatment of neurological disorders are provided in this report. The choice of biocompatible material dictates fabrication techniques as novel methods reduce the complexity of manufacture. Wireless power, the final hurdle to truly implantable neural interfaces, is discussed. These aspects are the driving force behind continued research: significant breakthroughs in any one of these areas will revolutionize the treatment of neurological disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.