Evidence map›Paper›PMID 34026234›Full record

ArticleGlobal mental health (Cambridge, England)2021

Behavioral impairment and cognition in Thai adolescents affected by HIV.

Payal B Patel, Andrew Belden, Ryan Handoko, Thanyawee Puthanakit, Stephen Kerr, Pope Kosalaraksa, Pradthana Ounchanum, Suparat Kanjanavanit, Linda Aurpibul, Chaiwat Ngampiyasakul and 5 more

Open access · goldAbstract read
In one paragraph

Article in Global mental health (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 2 countries.

Payal B PatelDepartment of Neurology, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-2984-9484
Andrew BeldenUniversity of Missouri, St. Louis, St. Louis, MO, USA.
Ryan HandokoYale University, New Haven, CT, USA.
Thanyawee PuthanakitDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Stephen KerrFaculty of Medicine, HIV-NAT, The Thai Red Cross AIDS Research Center and Biostatistics Centre, Chulalongkorn University, Bangkok, Thailand.
Pope KosalaraksaDepartment of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Pradthana OunchanumChiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
Suparat KanjanavanitNakornping Hospital, Chiang Mai, Thailand.
Linda AurpibulResearch Institute for Health Sciences (RIHES), Chiang Mai University, Thailand.
Chaiwat NgampiyasakulPrapokklao Hospital, Chantaburi, Thailand.
Wicharn LuesomboonQueen Savang Vadhana Memorial Hospital, Chonburi, Thailand.
Claude A MellinsHIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, and Columbia University, New York City, NY, USA.
Kathleen MaleeDepartment of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jintanat AnanworanichBill and Melinda Gates Medical Research Institute, Cambridge, MA, USA.
Robert PaulMissouri Institute of Mental Health, University of Missouri-St. Louis, Saint Louis, MO, USA.
Chulalongkorn University · THUniversity of Missouri–St. Louis · USChiang Mai University · THChiangRai Prachanukroh Hospital · THGates Foundation · USKhon Kaen University · THNakornping Hospital · THNew York Psychoanalytic Society and Institute · USNorthwestern University · USPrapokklao Hospital · THUniversity of Washington · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundCognitive and behavioral impairment are common in children living with perinatally acquired HIV (pHIV) and children exposed to HIV in utero but uninfected (HEU).

methodsWe sought to determine the prevalence of adverse behavioral symptomatology using a Thai-translated and validated version of the SNAP-IV questionnaire and assess cognitive function utilizing the Children's Color Trails Test, Delis-Kaplan Executive Function System, and the Wechsler Intelligence Scales, in our cohort of Thai adolescents (10-20 years old) with well-controlled pHIV compared to HEU and HIV-unexposed, uninfected youth. We then evaluated the interaction between HIV status, behavioral impairment, and executive function outcomes independent of demographic variables.

resultsAfter controlling for demographic factors of age and household income, adolescents with pHIV had higher inattentive symptomatology and poorer neuropsychological test scores compared to uninfected controls. Significant interactions were found between inattention and executive function across multiple neurocognitive tests.

conclusionsBehavioral impairment and poor executive functioning are present in adolescents with well-controlled pHIV compared to HIV-uninfected matched peers. The SNAP-IV questionnaire may be a useful tool to identify those with attentional impairment who may benefit from further cognitive testing in resource-limited settings.

Indexed as

Adolescentsbehavioral healthcognitionperinatal HIV

Identifiers

PMID34026234
PMCPMC8127634
OpenAlexW3126462905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.