Evidence map›Paper›PMID 34026057›Full record

ArticleFood science & nutrition2021

Synthesis of middle-long-middle structured intralipids by biological catalysis and the evaluation of intralipids' protective effect on liver injury rats.

Changsheng Liu, An'nan Chen, Li Xu, Tianqi Wang, Renwei Zhang, Juntao Xu, Yue Yu, Kaili Nie, Li Deng, Fang Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food science & nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Changsheng LiuBeijing Bioprocess Key Laboratory and State Key Laboratory of Chemical Resource Engineering College of Life Science and Technology Beijing University of Chemical Technology (BUCT) Beijing China.
An'nan ChenBeijing Bioprocess Key Laboratory and State Key Laboratory of Chemical Resource Engineering College of Life Science and Technology Beijing University of Chemical Technology (BUCT) Beijing China.
Li XuDepartment of Hepatobiliary Surgery China-Japan Friendship Hospital Beijing China.
Tianqi WangNational Research Institute for Family Planning Beijing China.
Renwei ZhangBeijing Bioprocess Key Laboratory and State Key Laboratory of Chemical Resource Engineering College of Life Science and Technology Beijing University of Chemical Technology (BUCT) Beijing China.
Juntao XuBeijing Bioprocess Key Laboratory and State Key Laboratory of Chemical Resource Engineering College of Life Science and Technology Beijing University of Chemical Technology (BUCT) Beijing China.
Yue YuBeijing Bioprocess Key Laboratory and State Key Laboratory of Chemical Resource Engineering College of Life Science and Technology Beijing University of Chemical Technology (BUCT) Beijing China.
Kaili NieBeijing Bioprocess Key Laboratory and State Key Laboratory of Chemical Resource Engineering College of Life Science and Technology Beijing University of Chemical Technology (BUCT) Beijing China.
Li DengBeijing Bioprocess Key Laboratory and State Key Laboratory of Chemical Resource Engineering College of Life Science and Technology Beijing University of Chemical Technology (BUCT) Beijing China.ORCID https://orcid.org/0000-0001-8792-529X
Fang WangBeijing Bioprocess Key Laboratory and State Key Laboratory of Chemical Resource Engineering College of Life Science and Technology Beijing University of Chemical Technology (BUCT) Beijing China.
Beijing University of Chemical Technology · CNChina-Japan Friendship Hospital · CNTianjin Municipal Research Institute for Family Planning · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intralipids are widely used to provide energy and necessary fatty acids for the patients. The structure of lipids may affect their function. We developed a bio-catalyzed route to prepare various intralipids and investigated the protective effect of intralipids against α-naphthylisothiocyanate (ANIT) induced liver injury rats, further discussing the structure-function relationship. The middle-long-middle (MLM) structural intralipid was synthesized through alcoholysis-esterification, and the influence factors were investigated. ANIT treatment caused liver injury, further making hepatocyte damage, and increasing related biochemical indexes, like aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and total bilirubin (TBIL). Especially, MLM-based and structoglyceride (STG) intralipids worked better in the early stage, to reduce the AST, ALT, and TBIL (

Indexed as

alcoholysisesterificationintralipidslipaseliver injuryMLM lipids

Identifiers

PMID34026057
PMCPMC8116870
OpenAlexW3136636436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.