Stereoselective synthesis and transformation of pinane-based 2-amino-1,3-diols.

Ákos Bajtel, Mounir Raji, Matti Haukka, Ferenc Fülöp, Zsolt Szakonyi

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In one paragraph

Article in Beilstein journal of organic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 54% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

The pinene scaffold: its occurrence, chemistry, synthetic utility, and pharmacological importance.RSC advances · 2022
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ákos Bajtel *Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary.ORCID https://orcid.org/0000-0003-2128-6522

Mounir Raji *Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.ORCID https://orcid.org/0000-0002-2661-1286

Matti HaukkaDepartment of Chemistry, University of Jyväskylä, POB 35, 40351 Jyväskylä, Finland.ORCID https://orcid.org/0000-0002-6744-7208

Ferenc FülöpInstitute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.ORCID https://orcid.org/0000-0003-1066-5287

Zsolt SzakonyiInstitute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.ORCID https://orcid.org/0000-0003-2432-8409

University of Szeged · HUUniversity of Jyväskylä · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A library of pinane-based 2-amino-1,3-diols was synthesised in a stereoselective manner. Isopinocarveol prepared from (-)-α-pinene was converted into condensed oxazolidin-2-one in two steps by carbamate formation followed by a stereoselective aminohydroxylation process. The relative stereochemistry of the pinane-fused oxazolidin-2-one was determined by 2D NMR and X-ray spectroscopic techniques. The regioisomeric spiro-oxazolidin-2-one was prepared in a similar way starting from the commercially available (1

Indexed as

2-amino-1,2-diolmonoterpeneoxazolidin-2-onestereoselectivetautomerism

Identifiers

PMID34025806

DOI10.3762/bjoc.17.80

PMCPMC8111431

OpenAlexW3158326104

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.