Evidence map›Paper›PMID 34025691›Full record

ArticleFrontiers in plant science2021

Towards Understanding Afghanistan Pea Symbiotic Phenotype Through the Molecular Modeling of the Interaction Between LykX-Sym10 Receptor Heterodimer and Nod Factors.

Yaroslav V Solovev, Anna A Igolkina, Pavel O Kuliaev, Anton S Sulima, Vladimir A Zhukov, Yuri B Porozov, Evgeny A Pidko, Evgeny E Andronov

Open access · goldAbstract read
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In one paragraph

Article in Frontiers in plant science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yaroslav V SolovevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Anna A IgolkinaAll-Russia Research Institute for Agricultural Microbiology (ARRIAM), Saint-Petersburg, Russia.
Pavel O KuliaevTheoMAT Research Group, ITMO University, Saint Petersburg, Russia.
Anton S SulimaAll-Russia Research Institute for Agricultural Microbiology (ARRIAM), Saint-Petersburg, Russia.
Vladimir A ZhukovAll-Russia Research Institute for Agricultural Microbiology (ARRIAM), Saint-Petersburg, Russia.
Yuri B PorozovWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Evgeny A PidkoInorganic Systems Engineering Group, Department of Chemical Engineering, Faculty of Applied Sciences, Delft University of Technology, Delft, Netherlands.
Evgeny E AndronovAll-Russia Research Institute for Agricultural Microbiology (ARRIAM), Saint-Petersburg, Russia.
All-Russian Research Institute of Agricultural Microbiology · RUITMO University · RUSechenov University · RUV.V. Dokuchaev Soil Science Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The difference in symbiotic specificity between peas of Afghanistan and European phenotypes was investigated using molecular modeling. Considering segregating amino acid polymorphism, we examined interactions of pea LykX-Sym10 receptor heterodimers with four forms of Nodulation factor (NF) that varied in natural decorations (acetylation and length of the glucosamine chain). First, we showed the stability of the LykX-Sym10 dimer during molecular dynamics (MD) in solvent and in the presence of a membrane. Then, four NFs were separately docked to one European and two Afghanistan dimers, and the results of these interactions were in line with corresponding pea symbiotic phenotypes. The European variant of the LykX-Sym10 dimer effectively interacts with both acetylated and non-acetylated forms of NF, while the Afghanistan variants successfully interact with the acetylated form only. We additionally demonstrated that the length of the NF glucosamine chain contributes to controlling the effectiveness of the symbiotic interaction. The obtained results support a recent hypothesis that the

Indexed as

COSMO-RS modelLykXmolecular dynamicsnod factorPeaplant-rhizobia symbiosisSym2

Identifiers

PMID34025691
PMCPMC8138044
OpenAlexW3159934250

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.