ArticleFrontiers in immunology2021
The Associations of Serum IL-37 With the Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Interleukins in community-acquired pneumonia: from biomarkers to precision medicine.Frontiers in immunology · 2026Review
- Neutrophil to lymphocyte ratio (NLR) and YKL-40 as potential markers for discriminating mycoplasma pneumoniae pneumonia from viral pneumonia in children.Open medicine (Warsaw, Poland) · 2026Article
- Associations of serum MANF with severity and prognosis in community-acquired pneumonia patients.Scientific reports · 2025Article
- Longitudinal relationships between serum ferritin and prognosis among severe community-acquired pneumonia patients.Frontiers in pharmacology · 2025Article
- Associations of Serum Legumain with Severity and Prognosis Among Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients.International journal of chronic obstructive pulmonary disease · 2025Article
- Blood cadmium concentration and pulmonary function injury: potential mediating role of oxidative stress in chronic obstructive pulmonary disease patients.BMC pulmonary medicine · 2024Article
- Serum transgelin is a novel prognostic biomarker for COVID-19 patients.Frontiers in immunology · 2024Article
- The levels of vitamins and cytokines in serum of elderly patients with community-acquired pneumonia: A case-control study.Health science reports · 2023Article
- Low 15d-PGJ2 status is associated with oxidative stress in chronic obstructive pulmonary disease patients.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- The association between serum complement C3a and severity in patients with community-acquired pneumonia.Frontiers in immunology · 2023Article
- Analysis of Correlation Between Serum Oncostatin-M and Disease Severity and Mortality in Hospitalized Patients with Community-Acquired Pneumonia.Journal of inflammation research · 2023Article
- Article
- Serum TRAIL predicts severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study.Internal and emergency medicine · 2022Article
- Serum Level of 4-Hydroxynonenal in Community-Acquired Pneumonia: A Potential Biomarker for Severity and Prognosis.Frontiers in medicine · 2022Article
- Cross-sectional and longitudinal associations of serum Cysteine-rich 61 with severity and prognosis among community-acquired pneumonia patients in China.Frontiers in medicine · 2022Article
- Associations among S100A4, Sphingosine-1-Phosphate, and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease.Oxidative medicine and cellular longevity · 2022Article
- Serum IL-27 predicts the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study.International journal of medical sciences · 2022Article
- Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study.BMC pulmonary medicine · 2021Article
- Serum CYR61 Is Associated With Airway Inflammation and Is a Potential Biomarker for Severity in Chronic Obstructive Pulmonary Disease.Frontiers in medicine · 2021Article
- Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia.Frontiers in immunology · 2021Article
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Abstract
Background: Recent evidences suggested that IL-37 may participate in the pathophysiology of community-acquired pneumonia (CAP). Nevertheless, its exact biological role was unknown. The objective of this study was to determine the associations of serum IL-37 with the severity and prognosis in CAP patients based on a retrospective cohort study. Methods: The whole of 120 healthy subjects and 240 CAP patients were summoned. Peripheral blood was collected and IL-37 was detected using ELISA. Results: Serum IL-37 was obviously decreased in CAP patients on admission. In addition, serum IL-37 was gradually decreased in parallel with CAP severity scores. Correlative analysis revealed that serum IL-37 was negatively associated with CAP severity scores and inflammatory cytokines. Further logistical regression found that reduction of serum IL-37 augmented the severity of CAP patients. Moreover, the follow-up research was performed in CAP patients. Serum lower IL-37 on admission prolonged the hospital stay in CAP patients. Serum IL-37 combination with PSI and CURB-65 had a stronger predictive capacity for death than IL-37 and CAP severity score alone in CAP patients. Conclusion: There are remarkably negative correlations between serum IL-37 with the severity and prognosis in CAP patients. Serum IL-37 on admission prolongs the hospital stay, demonstrating that IL-37 may involve in the process of CAP. Serum IL-37 may be regarded as a biomarker for diagnosis and prognosis for CAP patients.
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