Evidence map›Paper›PMID 34025376›Full record

ArticleFrontiers in human neuroscience2021

Neural Biomarkers Distinguish Severe From Mild Autism Spectrum Disorder Among High-Functioning Individuals.

Di Chen, Tianye Jia, Yuning Zhang, Miao Cao, Eva Loth, Chun-Yi Zac Lo, Wei Cheng, Zhaowen Liu, Weikang Gong, Barbara Jacquelyn Sahakian and 1 more

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Di ChenInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Tianye JiaInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Yuning ZhangCentre for Population Neuroscience and Precision Medicine, MRC SGDP Centre, IoPPN, King's College London, London, United Kingdom.
Miao CaoInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Eva LothSackler Institute for Translational Neurodevelopment, Department of Forensic and Neurodevelopmental Sciences, IoPPN, King's College London, London, United Kingdom.
Chun-Yi Zac LoInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Wei ChengInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Zhaowen LiuInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Weikang GongInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Barbara Jacquelyn SahakianDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
Jianfeng FengInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several previous studies have reported atypicality in resting-state functional connectivity (FC) in autism spectrum disorder (ASD), yet the relatively small effect sizes prevent us from using these characteristics for diagnostic purposes. Here, canonical correlation analysis (CCA) and hierarchical clustering were used to partition the high-functioning ASD group (i.e., the ASD discovery group) into subgroups. A support vector machine (SVM) model was trained through the 10-fold strategy to predict Autism Diagnostic Observation Schedule (ADOS) scores within the ASD discovery group (

Indexed as

autism diagnostic observation scheduleautism spectrum disorderfunctional magnetic resonance imaginghigh-functioning autismneural biomarker

Identifiers

PMID34025376
PMCPMC8134539

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.