Evidence map›Paper›PMID 34025133›Full record

ArticleJournal of ginseng research2021

Gintonin influences the morphology and motility of adult brain neurons via LPA receptors.

Do-Geun Kim, Hyeon-Joong Kim, Sun-Hye Choi, Sung Min Nam, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Man Hee Rhee, Seung-Yeol Nah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ginseng research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Brain plasticity and ginseng.Journal of ginseng research · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Do-Geun KimDementia Research Group, Korea Brain Research Institute, Cheomdanro 61, Daegu, Republic of Korea.
Hyeon-Joong KimGinsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Sun-Hye ChoiGinsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Sung Min NamGinsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Hyoung-Chun KimNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Republic of Korea.
Hyewhon RhimCenter for Neuroscience, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Ik-Hyun ChoDepartment of Convergence Medical Science, Brain Korea 21 Plus Program, and Institute of Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Man Hee RheeLaboratory of Veterinary Physiology & Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.
Seung-Yeol NahGinsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Kangwon National University · KRKonkuk University · KRWonkwang University · KRKorea Institute of Science and Technology · KRKyung Hee University · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGintonin is an exogenous ginseng-derived G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. LPA induces MATERIALS AND

methodsWe examined the effects of gintonin on

resultsWe found that treating hNPCs with gintonin induced morphological changes with a cell rounding following cell aggregation and return to individual neurons with time relapses. However, the

conclusionThe present report raises the possibility that gintonin could enter the brain and exert its influences on the migration and morphology of adult mouse brain neurons and possibly explains the therapeutic effects of neurological diseases behind the gintonin administration.

Indexed as

Adult brain neuronBBB, blood brain barrierbFGF, fibroblast growth factorBSA, bovine serum albuminDAPI, 4′,6-diamidino-2-phenylindoleDMEM, Dulbecco's modified Eagle's mediumDMSO, dimethyl sulfoxideEGF, epidermal growth factorFITC, fluorescein isothiocyanateGintoninHBSS, Hanks' Balanced Salt SolutionhNPC, hippocampal neural precursor cellsLPA, Lysophatidic AcidLPA receptorsMEM, Modified Eagle's mediumMorphology and migrationNECAB1, Neuronal calcium binding proteins 1NFH, neurofilament HOCT, optimum cutting temperaturePFA, paraformaldehydeROCK, Rho-associated protein kinase

Identifiers

PMID34025133
PMCPMC8134845
OpenAlexW3044184080

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.