Evidence map›Paper›PMID 34025131›Full record

ReviewJournal of ginseng research2021

Effect of Korean Red Ginseng on metabolic syndrome.

Sang Jun Yoon, Seul Ki Kim, Na Young Lee, Ye Rin Choi, Hyeong Seob Kim, Haripriya Gupta, Gi Soo Youn, Hotaik Sung, Min Jea Shin, Ki Tae Suk

Open access · goldAbstract readReview
In one paragraph

Review in Journal of ginseng research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Ginseng and health outcomes: an umbrella review.Frontiers in pharmacology · 2023
    Pooled it
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. The beneficial potential of ginseng for menopause.Journal of ginseng research · 2024
    Review
  19. Review
  20. Triterpenoid saponin fromMicrobiology spectrum · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sang Jun YoonInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Seul Ki KimInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Na Young LeeInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Ye Rin ChoiInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Hyeong Seob KimInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Haripriya GuptaInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Gi Soo YounInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Hotaik SungSchool of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Min Jea ShinInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Ki Tae SukInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea.
Hallym University · KRKyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic syndrome (MS) refers to a clustering of at least three of the following medical conditions: high blood pressure, abdominal obesity, hyperglycemia, low high-density lipoprotein level, and high serum triglycerides. MS is related to a wide range of diseases which includes obesity, diabetes, insulin resistance, cardiovascular disease, dyslipidemia, or non-alcoholic fatty liver disease. There remains an ongoing need for improved treatment strategies for MS. The most important risk factors are dietary pattern, genetics, old age, lack of exercise, disrupted biology, medication usage, and excessive alcohol consumption, but pathophysiology of MS has not been completely identified. Korean Red Ginseng (KRG) refers to steamed/dried ginseng, traditionally associated with beneficial effects such as anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. KRG has been often used in traditional medicine to treat multiple metabolic conditions. This paper summarizes the effects of KRG in MS and related diseases such as obesity, cardiovascular disease, insulin resistance, diabetes, dyslipidemia, or non-alcoholic fatty liver disease based on experimental research and clinical studies.

Indexed as

ACC, Acetyl-Coenzyme A carboxylaseADP, adenosine diphosphateAG, American ginseng extractAGE, advanced glycation end productAkt, protein kinase BALT, alanine aminotransferaseAMPK, AMP-activated protein kinaseAST, aspartate aminotransferaseBMI, body mass indexC/EBPα, CCAAT/enhancer-binding protein alphaCOX-2, cyclooxygenase-2CPT-1, carnitine palmitoyl transferase 1CPT, current perception thresholdCRP, C-reactive proteinCVD, Cardiovascular diseaseDBP, diastolic blood pressureDEN, diethyl nitrosamineEAT, epididymis adipose tissueEF, ejection fractionFABP4, fatty acid binding protein 4FAS, Fatty acid synthaseFFA, free fatty acidFR, fine root concentrationFS, fractional shorteningGBHT, ginseng-plus-Bai-Hu-TangGLUT, glucose transporter typeGPx, glutathione peroxidaseGS, ginsenosideGST, glutathione S-transferaseGST-P, glutathione S-transferase placental formGTT, glucose tolerance testHbA1c, glycosylated hemoglobinHCC, hepatocellular carcinomaHCEF-RG, hypotensive components-enriched fraction of red ginsengHDL, high-density lipoproteinHFD, High fat dietHOMA-IR, homeostasis model assessment of insulin resistance indexIL, interleukiniNOS, inducible nitric oxide synthaseInsulin resistanceI.P., intraperitoneal injectionIR, insulin resistanceITT, insulin tolerance testKRG, Korean Red GinsengLDL, low-density lipoproteinLex, lower extremitiesLPL, lipoprotein lipaseMDA, malondialdehydeMetabolic syndromeMMP, Matrix metallopeptidasesMS, Metabolic syndromeNAFLD, Non-alcoholic fatty liver diseaseNF-кB, nuclear factor kappa-light-chain-enhancer of activated B cellsNK cell, Natural killer cellNMDA-NR1, N-methyl-D-aspartate NR1Non-alcoholic fatty liver diseaseNO, nitric oxideNRF1, Nuclear respiratory factor 1Nrf2, Nuclear factor erythroid 2-related factor 2OLETF rat, Otsuka Long-Evans Tokushima fatty ratPanax ginsengPCG-1α, PPAR-γ coactivator-1αPI3K, phosphoinositide 3-kinasePPAR, peroxisome proliferator-activated receptorsPPD, protopanaxadiolPPT, protopanaxatriolREKRG, Rg3-enriched KRGRg3-KGE, Rg3-enriched KRG extractROS, Reactive oxygen speciesSBP, systolic blood pressureSCD, Stearoyl-Coenzyme A desaturaseSHR, spontaneously hypertensive ratSREBP-1C, Sterol regulatory element-binding protein 1STAT5, Signal transducer and activator of transcription 5STZ, streptozotocinTBARS, thiobarbituric acid reactive substancest-BHP, tert-butyl hyperoxideTC, total cholesteroltGST, total glutathioneTG, triglycerideTNF, tumor necrosis factorUCP, Mitochondrial uncoupling proteinsVLDL, very low-density lipoprotein

Identifiers

PMID34025131
PMCPMC8134847
OpenAlexW3105145706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.